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01-106 FGF-2 / basic FGF Protein, Human recombinant

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01-106
25 µg  
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Overview

Key Spec Table

Key ApplicationsSpeciesSource
CULTHuman Recombinant DNA expressed in yeast (S. cerevisiae).
Description
Catalogue Number01-106
Brand Family Upstate
Trade Name
  • Upstate
DescriptionFGF-2 / basic FGF Protein, Human recombinant
Product Information
PresentationLiquid in PBS, pH 7.4, containing 0.5% BSA and 0.1% CHAPS.
Quality LevelMQ100
Applications
ApplicationThe FGF-2 / basic FGF Protein, Human recombinant is available in a 25 µg format.
Key Applications
  • Cell Culture
Biological Information
SourceRecombinant DNA expressed in yeast (S. cerevisiae).
Entrez Gene Number
Entrez Gene SummaryThe protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF.
Gene Symbol
  • FGF2
  • Prostatropin
  • BFGF
  • prostatropin
  • HBGF-2
  • FGFB
Purification MethodHeparin-Sepharose™ chromatography
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P09038 # The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. There are differences in the tissue distribution and concentration of these 2 growth factors.
SIZE: 155 amino acids; 17254 Da
SUBUNIT: Monomer. Interacts with CSPG4 and FGFBP1. Found in a complex with FGFBP1, FGF1 and FGF2.
SIMILARITY: SwissProt: P09038 ## Belongs to the heparin-binding growth factors family.
MISCELLANEOUS: This protein binds heparin more strongly than does aFGF.
Stem Cell Type
  • Human Embryonic Stem Cells
  • Neural Stem Cells
  • Epithelial Cells
  • Mesenchymal Stem Cells
  • Pancreatic Stem Cells
  • Induced Pluripotent Stem Cells
Product Usage Statements
Quality AssuranceRoutinely evaluated by Biological Activity Assay. Cultures of fetal bovine heart endothelial (FBHE) cells grown for five days in RD medium containing FBS, heparin, and FGF-2 showed more cells than cultures of FBHE cells grown in same medium without FGF-2.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Packaging Information
Material Size25 µg
Global Trade Item Number
Catalogue Number GTIN
01-106 04053252332869