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341209 EUK-8 - CAS 53177-12-1 - Calbiochem

A synthetic salen-manganese complex with high superoxide dismutase (SOD) and catalase-mimic activities, and oxyradical scavenging activities.

EUK-8 - CAS 53177-12-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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341209
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
53177-12-1C₁₆H₁₄ClMnN₂O₂

Products

Catalogue NumberPackaging Qty/Pack
341209-10MG Plastic ampoule 10 mg
Description
OverviewA synthetic salen-manganese complex with high superoxide dismutase (SOD) and catalase-mimic activities, and oxyradical scavenging activities. Shown to have protective effects in numerous models for disease processes associated with oxidative stress, including inflammation, cardiovascular diseases, acute critical illness, autoimmune diseases, and neurological disorders. Useful in preventing cardiac damage caused by ischemic reperfusion. Also prevents β-amyloid peptide (Aβ)-induced free radical formation and lipid peroxidation. Imparts protection against Aβ40 and Aβ42 toxicity in hippocampal cultures.
Catalogue Number341209
Brand Family Calbiochem®
References
ReferencesColparet, E. E. and Lefebure, R. A. 2000. Br. J. Pharmacol. 130, 359.
Brandier, C., et al. 1997. J. Vasc. Res. 34, 49.
Doctrow, S.R., et al. 1997. Adv. Pharmacol. 38, 247.
Bruce, A.J., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 2312.
Pucheu, S., et al. 1996. Cardiovasc. Drug Ther. 10, 331.
Baudry, M., et al. 1993. Biochem. Biophys. Res. Commun. 192, 964.
Product Information
CAS number53177-12-1
ATP CompetitiveN
DeclarationNot available for sale in Africa, Australia, Great Britain, Europe, Latvia, New Zealand, and the United States.
FormDark brown solid
Hill FormulaC₁₆H₁₄ClMnN₂O₂
Chemical formulaC₁₆H₁₄ClMnN₂O₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetSuperoxide dismutase (SOD) and catalase-mimic activities, and oxyradical scavenging activities
Purity≥90% by elemental analysis
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 weeks at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
341209-10MG 04055977215465

Documentation

EUK-8 - CAS 53177-12-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

EUK-8 - CAS 53177-12-1 - Calbiochem Certificates of Analysis

TitleLot Number
341209

References

Reference overview
Colparet, E. E. and Lefebure, R. A. 2000. Br. J. Pharmacol. 130, 359.
Brandier, C., et al. 1997. J. Vasc. Res. 34, 49.
Doctrow, S.R., et al. 1997. Adv. Pharmacol. 38, 247.
Bruce, A.J., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 2312.
Pucheu, S., et al. 1996. Cardiovasc. Drug Ther. 10, 331.
Baudry, M., et al. 1993. Biochem. Biophys. Res. Commun. 192, 964.

Brochure

Title
Pathways and Biomarkers of Oxidative Stress
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision24-June-2008 RFH
DescriptionA synthetic salen-manganese complex with high superoxide dismutase (SOD), catalase, and oxyradical scavenger activities. Shown to have protective effects in numerous models for disease processes associated with oxidative stress, including inflammation, cardiovascular diseases, acute critical illness, autoimmune diseases, and neurological disorders. Useful in preventing cardiac damage caused by ischemic reperfusion. Also prevents β-amyloid peptide (Aβ)-induced free radical formation and lipid peroxidation and imparts protection against Aβ40 and Aβ42 toxicity in hippocampal cultures.
FormDark brown solid
Intert gas (Yes/No) Packaged under inert gas
CAS number53177-12-1
Chemical formulaC₁₆H₁₄ClMnN₂O₂
Structure formulaStructure formula
Purity≥90% by elemental analysis
SolubilityDMSO (20 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 weeks at -20°C.
Toxicity Standard Handling
ReferencesColparet, E. E. and Lefebure, R. A. 2000. Br. J. Pharmacol. 130, 359.
Brandier, C., et al. 1997. J. Vasc. Res. 34, 49.
Doctrow, S.R., et al. 1997. Adv. Pharmacol. 38, 247.
Bruce, A.J., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 2312.
Pucheu, S., et al. 1996. Cardiovasc. Drug Ther. 10, 331.
Baudry, M., et al. 1993. Biochem. Biophys. Res. Commun. 192, 964.