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263200 Dephostatin - CAS 151606-30-3 - Calbiochem

Dephostatin - CAS 151606-30-3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: PTP Inhibitor VII

Primary Target: protein tyrosine phosphatase activity from human neoplastic cell line
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
151606-30-3C₇H₈N₂O₃
Description
Overview

This product has been discontinued.



Protein tyrosine phosphatase inhibitor. Competitively inhibits protein tyrosine phosphatase activity in membrane preparations from human neoplastic T cell line (IC50 = 7.7 µM). Reported to mobilize intracellular calcium stores. Could serve as a stable NO donor for S-nitrosylation of proteins.
Catalogue Number263200
Brand Family Calbiochem®
SynonymsPTP Inhibitor VII
References
ReferencesLajas, A.I., et al. 2000. Mol. Cell Biochem. 205, 163.
Guo, Z., et al. 1996. Bioorganic Med. Chem. Lett. 6, 573.
Watanabe, T., et al. 1995. J. Antibiot. 48, 1460.
Yu, L., et al. 1995. Bioorg. Med. Chem. Lett. 9, 1003.
Imoto, M., et al. 1993. J. Antibiot. 46, 1342.
Product Information
CAS number151606-30-3
ATP CompetitiveY
FormBrown powder
Hill FormulaC₇H₈N₂O₃
Chemical formulaC₇H₈N₂O₃
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetprotein tyrosine phosphatase activity from human neoplastic cell line
Primary Target IC<sub>50</sub>7.7 µM against protein tyrosine phosphatase activity in membrane preparations from human neoplastic T cell line
Purity≥90% by HPLC
SourceStreptomyces sp.
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSCZ9021800
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) under an inert gas. Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
263200 0

Documentation

Dephostatin - CAS 151606-30-3 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Dephostatin - CAS 151606-30-3 - Calbiochem Certificates of Analysis

TitleLot Number
263200

References

Reference overview
Lajas, A.I., et al. 2000. Mol. Cell Biochem. 205, 163.
Guo, Z., et al. 1996. Bioorganic Med. Chem. Lett. 6, 573.
Watanabe, T., et al. 1995. J. Antibiot. 48, 1460.
Yu, L., et al. 1995. Bioorg. Med. Chem. Lett. 9, 1003.
Imoto, M., et al. 1993. J. Antibiot. 46, 1342.

Brochure

Title
Protein Phosphatases Technical Bulletin
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-June-2008 RFH
SynonymsPTP Inhibitor VII
DescriptionProtein tyrosine phosphatase inhibitor. Competitively inhibits protein tyrosine phosphatase activity in a membrane preparation from a human neoplastic T-cell line (IC50 = 7.7 µM). Inhibits homogenous recombinant Yersinia and mammalian protein tyrosine phosphatases in a concentration and time-dependent manner.
FormBrown powder
Intert gas (Yes/No) Packaged under inert gas
SourceStreptomyces sp.
CAS number151606-30-3
RTECSCZ9021800
Chemical formulaC₇H₈N₂O₃
Structure formulaStructure formula
Purity≥90% by HPLC
SolubilityChloroform or DMSO (5 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) under an inert gas. Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesLajas, A.I., et al. 2000. Mol. Cell Biochem. 205, 163.
Guo, Z., et al. 1996. Bioorganic Med. Chem. Lett. 6, 573.
Watanabe, T., et al. 1995. J. Antibiot. 48, 1460.
Yu, L., et al. 1995. Bioorg. Med. Chem. Lett. 9, 1003.
Imoto, M., et al. 1993. J. Antibiot. 46, 1342.