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260930 DNA Polymerase Sliding Clamp Inhibitor, RU7

The DNA Polymerase Sliding Clamp Inhibitor, RU7, also referenced under CAS 355400-87-2, controls the biological activity of E. coli DNA polymerase III. This small molecule/inhibitor is primarily used for Cell Structure applications.

DNA Polymerase Sliding Clamp Inhibitor, RU7 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: E. coli Pol III/β-clamp Interaction Inhibitor

260930
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
355400-87-2C₁₄H₁₁Br₂NO₅S₂

Products

Catalogue NumberPackaging Qty/Pack
260930-10MG Plastic ampoule 10 mg
Description
Overview

This product has been discontinued.





A 2-thio-thiazolidinone compound that binds the peptide-binding pocket of E. coli β-clamp and disrupts E. coli DNA polymerase III binding to β-clamp, but not the binding of Pol C to the β-clamp of the gram-positive Streptococcus pyogenes species. Shown to selectively inhibit the polymerase activity of E. coli Pol III (Ki = 10 µM) over Pol II and IV in β-dependent replicase assays, while exhibiting little effect toward the β-independent activity of E. coli Pol I Klenow fragment or the yeast PCNA-dependent Pol δ activity of the Saccharomyces cereviase species.
Catalogue Number260930
Brand Family Calbiochem®
SynonymsE. coli Pol III/β-clamp Interaction Inhibitor
References
ReferencesGeorgescu, R.E., et al. 2008. Proc. Natl. Acad. Sci. USA 105, 11116.
Product Information
CAS number355400-87-2
FormYellow solid
Hill FormulaC₁₄H₁₁Br₂NO₅S₂
Chemical formulaC₁₄H₁₁Br₂NO₅S₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°:C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
260930-10MG 04053252041334

Documentation

DNA Polymerase Sliding Clamp Inhibitor, RU7 SDS

Title

Safety Data Sheet (SDS) 

DNA Polymerase Sliding Clamp Inhibitor, RU7 Certificates of Analysis

TitleLot Number
260930

References

Reference overview
Georgescu, R.E., et al. 2008. Proc. Natl. Acad. Sci. USA 105, 11116.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision06-April-2011 RFH
SynonymsE. coli Pol III/β-clamp Interaction Inhibitor
DescriptionA 2-thio-thiazolidinone compound that binds the peptide-binding pocket of E. coli β-clamp and disrupts E. coli DNA polymerase III binding to β-clamp, but not the binding of Pol C to the β-clamp of the gram-positive Streptococcus pyogenes species. Shown to selectively inhibit the polymerase activity of E. coli Pol III (Ki = 10 µM) over Pol II & IV in β-dependent replicase assays, while exhibiting little effect toward the β-independent activity of E. coli Pol I Klenow fragment or the yeast PCNA-dependent Pol δ activity of the Saccharomyces cereviase species.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number355400-87-2
Chemical formulaC₁₄H₁₁Br₂NO₅S₂
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°:C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesGeorgescu, R.E., et al. 2008. Proc. Natl. Acad. Sci. USA 105, 11116.