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251406 D-Amino Acid Oxidase Inhibitor III, AS057278 - CAS 402-61-9 - Calbiochem

251406
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Overview

Key Spec Table

CAS #Empirical Formula
402-61-9C₅H₆N₂O₂

Products

Catalogue NumberPackaging Qty/Pack
251406-50MG Glass bottle 50 mg
Description
OverviewA cell-permeable pyrazolocarboxylic acid that acts as a selective D-amino acid oxidase (DAO/DAAO/DAMOX/OXDA) inhibitor (IC50 = 910 nM against human DAO; [D-ser] = 10 mM) and effectively protects DAO overexpressing cultures from oxidative stress-induced cell death upon D-Ser (50 mM) exposure (ED50 ≤3.95 µM), while exhibiting little affinity toward NMDAR glycine binding site or inhibitory activity against D-aspartate oxidase (DDO/DSOX). Reported to be orally available and blood-brain barrier-permeant in rats and effectively prevent PCP (phencyclidine) from suppressing PPI (prepulse inhibition) response in mice (single 80 mg/kg or 56X 20 mg/kg/12 h b.i.d. oral dosages) in vivo.
Catalogue Number251406
Brand Family Calbiochem®
Synonyms5-methyl-1H-pyrazole-3-carboxylic acid, DAAO Inhibitor III
References
ReferencesSmith, S., et al. 2010. Open Med. Chem. J. 27, 3.
Williams, M. 2009. Biochem. Pharmacol. 78, 1360.
Adage, T., et al. 2008. Eur. Neuropsychopharmacol. 18, 200.
Product Information
CAS number402-61-9
FormWhite solid
Hill FormulaC₅H₆N₂O₂
Chemical formulaC₅H₆N₂O₂
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetDAAO
Primary Target IC<sub>50</sub>910 nM
Purity≥99% by HPLC
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
251406-50MG 04055977199215