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235035 Coronavirus Main Proteinase Inhibitor

Coronavirus Main Proteinase Inhibitor MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: CoV Mpro Inhibitor, 3CLpro Inhibitor, Cbz-VNSTLQ-CMK

235035
  
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Overview

Replacement Information
Description
OverviewA hexapeptidyl chloromethyl ketone that acts as an irreversible substrate-analog inhibitor of several viral proteinases. Shown to covalently modify the active site cysteine residue. The peptide is derived from the P6 - P1 residues of the NH2-terminal autoprocessing site of porcine TGEV Mpro (transmissible gastroenteritis virus main proteinase) and is expected to bind to all other coronavirus homologs, such as human SARS-CoV Mpro and HCoV 229E Mpro, in a similar manner and with similar affinity.
Catalogue Number235035
Brand Family Calbiochem®
SynonymsCoV Mpro Inhibitor, 3CLpro Inhibitor, Cbz-VNSTLQ-CMK
References
ReferencesAnand, K., et al. 2003. Science 300, 1763.
Product Information
FormWhite solid
Hill FormulaC₃₆H₅₅ClN₈O₁₂
Chemical formulaC₃₆H₅₅ClN₈O₁₂
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Peptide SequenceZ-Val-Asn-Ser-Thr-Leu-Gln-CMK
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Irritant
Storage -20°C
Protect from Light Protect from light
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
235035 0

Documentation

Coronavirus Main Proteinase Inhibitor Certificates of Analysis

TitleLot Number
235035

References

Reference overview
Anand, K., et al. 2003. Science 300, 1763.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision09-June-2008 RFH
SynonymsCoV Mpro Inhibitor, 3CLpro Inhibitor, Cbz-VNSTLQ-CMK
DescriptionA hexapeptidyl chloromethyl ketone that acts as an irreversible substrate-analog inhibitor of several viral proteinases. Shown to covalently modify the active site cysteine residue. The peptide is derived from the P6 - P1 residues of the NH2-terminal autoprocessing site of porcine TGEV Mpro (transmissible gastroenteritis virus main proteinase) and is expected to bind to all other coronavirus homologs, such as human SARS-CoV Mpro and HCoV 229E Mpro, in a similar manner and with similar affinity.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₃₆H₅₅ClN₈O₁₂
Peptide SequenceZ-Val-Asn-Ser-Thr-Leu-Gln-CMK
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml) or H₂O (1 mg/ml)
Storage Protect from moisture
Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Irritant
ReferencesAnand, K., et al. 2003. Science 300, 1763.