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CC118 Chicken Tenascin

Chicken Tenascin MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Key Applications: Positive Control, Cell Culture
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CC118
50 µg  
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Overview

Replacement Information

Key Spec Table

Key Applications
PC, CULT
Description
Catalogue NumberCC118
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionChicken Tenascin
OverviewTenascin is a large glycoprotein that forms disulfide-linked hexamers. It is made up of repeated structural domains including EGF-like repeats, fibronectin type III repeats, and a region homologous to fibrinogen. Splice variants of tenascin differ in their number of fibronectin type III repeats. Tenascin is expressed in distinctive spatial and temporal patterns in most embryonic tissues at sites of tissue remodeling and cell migration. There is little expression of tenascin in adult tissues except, again, at sites of tissue remodeling and cell migration such as surrounding tumors, in healing wounds, and in branching or damaged blood vessels. Tenascin binds to several cell-surface receptors and mediates cell-substrate adhesion. Nevertheless, tenascin is frequently referred to as an anti-adhesion molecule because for a variety of cell types the presence of tenascin inhibits adhesion to other ECM proteins present. This effect occurs because the binding of tenascin to certain receptors inhibits cell spreading and thereby blocks the stabilization of adhesion that results from cell preading in vitro assays.
Alternate Names
  • Cytotactin
  • Tenascin-C
References
Product Information
PresentationProvided as a liquid in PBS, containing no preservatives.
Quality LevelMQ100
Applications
Key Applications
  • Positive Control
  • Cell Culture
Biological Information
Concentration0.5 mg/mL
PurityIsolated from embryonic chicken brains by chromatographic methods. Contains three characteristic polypeptide chains (220, 200, and 190 kDa) that migrate on SDS gels as a high molecular weight multimer under non-reducing conditions.
SourcePurified from embrionic chicken brains.
UniProt Number
Stem Cell Type
  • Mouse Embryonic Stem Cells
  • Mesenchymal Stem Cells
  • Neural Stem Cells
  • Hematopoietic Stem Cells
  • Epithelial Cells
  • Pancreatic Stem Cells
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStore at -20°C for up to 12 months. Avoid repeated freeze/thaw.
Packaging Information
Material Size50 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
CC118 04053252678813

Documentation

Chicken Tenascin SDS

Title

Safety Data Sheet (SDS) 

Chicken Tenascin Certificates of Analysis

TitleLot Number
CHICKEN TENASCIN - 3897690 3897690
CHICKEN TENASCIN -2615117 2615117
CHICKEN TENASCIN PURIFIED PROTEIN 2935439
CHICKEN TENASCIN PURIFIED PROTEIN 2907172
CHICKEN TENASCIN PURIFIED PROTEIN - 4030510 4030510
Chicken Tenascin Purified Protein 2472937

References

Reference overviewPub Med ID
A detailed structural model of cytotactin: protein homologies, alternative RNA splicing, and binding regions
Jones, F S, et al
Proc Natl Acad Sci USA, 86:1905-9 (1989)  1989

2467292 2467292
Two contrary functions of tenascin: dissection of the active sites by recombinant tenascin fragments.
Spring, J, et al.
Cell, 59: 325-34 (1989)  1989

Show Abstract 		2478295 2478295