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220320 Chetomin, Chaetomium sp. - CAS 1403-36-7 - Calbiochem

A cell-permeable dithiodiketopiperazine antimicrobial agent that disrupts the CH1 domain structure of p300.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: CS-1, CTM

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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1403-36-7C₃₁H₃₀N₆O₆S₄
Description
OverviewA cell-permeable dithiodiketopiperazine antimicrobial agent that disrupts the CH1 domain structure of p300, an important mediator of tumor hypoxia adaptation, and prevents the association of p300 with CH1-interacting proteins, such as HIF-1α and STAT2. Shown to attenuate hypoxia-induced transcription in vitro (IC50 = 20 nM and < 10 nM in inhibiting secreted and cellular VEGF, respectively, in Hep38 cells) and inhibit tumor growth by inducing necrosis in vivo (1 mg/kg, i.v., daily in tumor xenografted NCr/Nude mice). Does not affect the transcriptional activity of PAR, SREBP2, or SRC-1, whose association with p300 is not mediated via CH1 domain.
Catalogue Number220320
Brand Family Calbiochem®
SynonymsCS-1, CTM
References
ReferencesFujimoto, H., et al. 2004. J. Nat. Prod. 67, 98.
Kung, A.L., et al. 2004. Cancer Cell 6, 33.
Product Information
CAS number1403-36-7
FormOff-white solid
Hill FormulaC₃₁H₃₀N₆O₆S₄
Chemical formulaC₃₁H₃₀N₆O₆S₄
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSFM3038000
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution in fresh, anhydrous DMSO, aliquot and freeze (-20°C). Stock solutions for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
220320 0

Documentation

Chetomin, Chaetomium sp. - CAS 1403-36-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Chetomin, Chaetomium sp. - CAS 1403-36-7 - Calbiochem Certificates of Analysis

TitleLot Number
220320

References

Reference overview
Fujimoto, H., et al. 2004. J. Nat. Prod. 67, 98.
Kung, A.L., et al. 2004. Cancer Cell 6, 33.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision25-June-2009 RFH
SynonymsCS-1, CTM
DescriptionA cell-permeable antimicrobial that disrupts the CH1 domain structure of p300, an important mediator of tumor hypoxia adaptation. Prevents the association of p300 with CH1-interacting proteins, such as HIF-1α and STAT2. Shown to attenuate hypoxia-induced transcription in vitro (IC50 = 20 nM and <10 nM in inhibiting secreted and cellular VEGF, respectively, in Hep38 cells) and inhibit tumor growth by inducing necrosis in vivo (1 mg/kg, i.v., daily in tumor xenografted NCr/Nude mice). Exhibits no effect on the transcriptional activity of PAR, SREBP2, or SRC-1, whose association with p300 is not mediated via CH1 domain.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1403-36-7
RTECSFM3038000
Chemical formulaC₃₁H₃₀N₆O₆S₄
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution in fresh, anhydrous DMSO, aliquot and freeze (-20°C). Stock solutions for up to 3 months at -20°C.
Toxicity Toxic
ReferencesFujimoto, H., et al. 2004. J. Nat. Prod. 67, 98.
Kung, A.L., et al. 2004. Cancer Cell 6, 33.