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219478 Cdk4 Inhibitor III - CAS 265312-55-8 - Calbiochem

The Cdk4 Inhibitor III, also referenced under CAS 265312-55-8, controls the biological activity of Cdk4. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-(N-(4-Methylphenyl)amino)-2-methyl-4,7-dioxobenzothiazole, Ryuvidine

Primary Target: Cdk4
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
265312-55-8C₁₅H₁₂N₂O₂S

Products

Catalogue NumberPackaging Qty/Pack
219478-5MG Plastic ampoule 5 mg
Description
OverviewA cell-permeable dioxobenzothiazole compound that acts a selective Cdk4 inhibitor (IC50 = 6.0 µM for Cdk4/D1 and > 200 µM for Cdk2/A). Exhibit better cytotoxic potential against cancer cells (IC50 = 0.61, 1.08, 0.30, and 1.21 µg/ml against A 549, Col 1, HL-60, and HepG2 tumor cells, respectively) than Cisplatin (Cat. No. 232120).
Catalogue Number219478
Brand Family Calbiochem®
Synonyms5-(N-(4-Methylphenyl)amino)-2-methyl-4,7-dioxobenzothiazole, Ryuvidine
References
ReferencesRyu, C.K., et al. 2000. Bioorg. Med. Chem. Lett. 10, 461.
Product Information
CAS number265312-55-8
ATP CompetitiveN
FormBlack-purple solid
Hill FormulaC₁₅H₁₂N₂O₂S
Chemical formulaC₁₅H₁₂N₂O₂S
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCdk4
Primary Target IC<sub>50</sub>6.0 µM for Cdk4/D1 and > 200 µM for Cdk2/A
Purity≥90% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
219478-5MG 04055977218558

Documentation

Cdk4 Inhibitor III - CAS 265312-55-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Cdk4 Inhibitor III - CAS 265312-55-8 - Calbiochem Certificates of Analysis

TitleLot Number
219478

References

Reference overview
Ryu, C.K., et al. 2000. Bioorg. Med. Chem. Lett. 10, 461.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision11-October-2013 JSW
Synonyms5-(N-(4-Methylphenyl)amino)-2-methyl-4,7-dioxobenzothiazole, Ryuvidine
DescriptionA cell-permeable dioxobenzothiazole compound that acts a selective Cdk4 inhibitor (IC50 = 6.0 µM for Cdk4/D1 and >200 µM for Cdk2/A). Exhibit better cytotoxic potential against cancer cells (IC50 = 0.61, 1.08, 0.30, and 1.21 µg/ml against A 549, Col 1, HL-60, and HepG2 tumor cells, respectively) than Cisplatin (Cat. No. 232120).
FormBlack-purple solid
Intert gas (Yes/No) Packaged under inert gas
CAS number265312-55-8
Chemical formulaC₁₅H₁₂N₂O₂S
Structure formulaStructure formula
Purity≥90% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesRyu, C.K., et al. 2000. Bioorg. Med. Chem. Lett. 10, 461.