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219448 Cdk2/5 Inhibitor

The Cdk2/5 Inhibitor, also referenced under CAS 21886-12-4, controls the biological activity of Cdk2/5. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Cdk2/5 Inhibitor MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: PNU 112455A, N⁴-(6-Aminopyrimidin-4-yl)-sulfanilamide, HCI

Primary Target: CDK2
219448
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
21886-12-4C₁₀H₁₁N₅O₂S · HCl
Description
Overview

This product has been discontinued.





An aminopyrimidine derivative that acts as a selective and ATP-competitive inhibitor of Cdk2/cyclin E and Cdk5/p25 (Ki = 2 µM). Binds to the ATP-binding pocket of Cdk2. Does not affect the activities of c-Met, IGF-1 receptor tyrosine kinase, cAMP-dependent kinase, and ERK2 at concentrations as high as 100 µM.
Catalogue Number219448
Brand Family Calbiochem®
SynonymsPNU 112455A, N⁴-(6-Aminopyrimidin-4-yl)-sulfanilamide, HCI
References
ReferencesClare, P.M., et al. 2001. J. Biol. Chem. 276, 48292.
Product Information
CAS number21886-12-4
ATP CompetitiveY
FormWhite solid
Hill FormulaC₁₀H₁₁N₅O₂S · HCl
Chemical formulaC₁₀H₁₁N₅O₂S · HCl
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetCDK2
Primary Target K<sub>i</sub>2 µM for Cdk2/cyclin E and Cdk5/p25
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
219448 0

Documentation

Cdk2/5 Inhibitor SDS

Title

Safety Data Sheet (SDS) 

Cdk2/5 Inhibitor Certificates of Analysis

TitleLot Number
219448

References

Reference overview
Clare, P.M., et al. 2001. J. Biol. Chem. 276, 48292.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-April-2011 RFH
SynonymsPNU 112455A, N⁴-(6-Aminopyrimidin-4-yl)-sulfanilamide, HCI
DescriptionAn aminopyrimidine derivative that acts as a selective inhibitor of Cdk2/cyclin E and Cdk5/p25 (Ki = 2 µM). The inhibition is competitive with respect to ATP. Crystallographic studies indicate that the inhibitor binds to the ATP-binding pocket of the enzyme. Does not affect the activity of c-met, insulin-like growth factor I receptor tyrosine kinase (IGF-IR), cAMP-dependent kinase, or ERK2 even at a 100 µM concentration.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number21886-12-4
Chemical formulaC₁₀H₁₁N₅O₂S · HCl
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesClare, P.M., et al. 2001. J. Biol. Chem. 276, 48292.