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217695 Cdk1 Inhibitor - CAS 220749-41-7 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-(2-Chloro-3-indolylmethylene)-1,3-dihydroindol-2-one

Primary Target: Cdk1
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
220749-41-7C₁₇H₁₁ClN₂O
Description
Overview

This product has been discontinued.



A cell-permeable indolylmethylene-2-indolinone derivative that exhibits potent anti-proliferative properties (IC50 = 2 µM HeLa cells). Acts as a selective, reversible and ATP-competitive inhibitor of Cdk1/cyclin B (IC50 = 5.8 µM). Also inhibits Cdk5 with a IC50 = 25 µM. Binds to the ATP pocket on the Cdk1 active site. Does not affect the activity of GSK-3β even at 100 µM concentrations.
Catalogue Number217695
Brand Family Calbiochem®
Synonyms3-(2-Chloro-3-indolylmethylene)-1,3-dihydroindol-2-one
References
ReferencesAndreani, A., et al. 2000. Anticancer Drug Des. 15, 447.
Andreani, A., et al. 1996. Anticancer Res. 16, 3585.
Product Information
CAS number220749-41-7
ATP CompetitiveY
FormOrange solid
Hill FormulaC₁₇H₁₁ClN₂O
Chemical formulaC₁₇H₁₁ClN₂O
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCdk1
Primary Target IC<sub>50</sub>2 µM for anti-proliferative properties in HeLa cells; 5.8 µM against Cdk1/cyclin B
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
217695 0

Documentation

Cdk1 Inhibitor - CAS 220749-41-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Cdk1 Inhibitor - CAS 220749-41-7 - Calbiochem Certificates of Analysis

TitleLot Number
217695

References

Reference overview
Andreani, A., et al. 2000. Anticancer Drug Des. 15, 447.
Andreani, A., et al. 1996. Anticancer Res. 16, 3585.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision16-December-2009 RFH
Synonyms3-(2-Chloro-3-indolylmethylene)-1,3-dihydroindol-2-one
DescriptionA cell-permeable indolylmethylene-2-indolinone derivative that exhibits potent anti-proliferative properties (IC50 = 2 µM in HeLa cells). Acts as a selective, reversible and ATP-competitive inhibitor of cyclin-dependent kinase-1/cyclin B (IC50 = 5.8 µM for Cdk1 and 25 µM for Cdk5). Does not affect the activity of GSK-3β even at 100 µM concentrations. Binds to the ATP pocket in the Cdk1 active site.
FormOrange solid
Intert gas (Yes/No) Packaged under inert gas
CAS number220749-41-7
Chemical formulaC₁₇H₁₁ClN₂O
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (200 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesAndreani, A., et al. 2000. Anticancer Drug Des. 15, 447.
Andreani, A., et al. 1996. Anticancer Res. 16, 3585.