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219457 Cdk Inhibitor, p35 - CAS 471270-60-7 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-(3-Hydroxypropylamino)-6-(o-hydroxybenzylamino)-9-isopropylpurine

Primary Target: CDK1, CDK2
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
471270-60-7C₁₈H₂₄N₆O₂
Description
Overview

This product has been discontinued.



An analog of Olomoucine (Cat. No. 495620) that acts as a potent inhibitor of Cdk1 (IC50 = 100 nM) and Cdk2 (IC50 = 80 nM). Also displays anti-proliferative and pro-apoptotic effects. The correlation between inhibition of Cdk1/Cdk2 and inhibition of cell proliferation suggests that the anti-proliferative effects are due, in part, to Cdk inhibition.
Catalogue Number219457
Brand Family Calbiochem®
Synonyms2-(3-Hydroxypropylamino)-6-(o-hydroxybenzylamino)-9-isopropylpurine
References
ReferencesVermeulen, K., et al. 2002. Leukemia 16, 299.
Product Information
CAS number471270-60-7
ATP CompetitiveN
FormYellow solid
Hill FormulaC₁₈H₂₄N₆O₂
Chemical formulaC₁₈H₂₄N₆O₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCDK1, CDK2
Primary Target IC<sub>50</sub>100 nM, 80 nM, against Cdk1 and Cdk2, respectively
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
219457 0

Documentation

Cdk Inhibitor, p35 - CAS 471270-60-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Cdk Inhibitor, p35 - CAS 471270-60-7 - Calbiochem Certificates of Analysis

TitleLot Number
219457

References

Reference overview
Vermeulen, K., et al. 2002. Leukemia 16, 299.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-April-2011 RFH
Synonyms2-(3-Hydroxypropylamino)-6-(o-hydroxybenzylamino)-9-isopropylpurine
DescriptionAn analog of Olomoucine (Cat. No. 495620) that acts as a potent inhibitor of Cdk1 (IC50 = 100 nM) and Cdk2 (IC50 = 80 nM). Also displays anti-proliferative and pro-apoptotic effects.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number471270-60-7
Chemical formulaC₁₈H₂₄N₆O₂
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesVermeulen, K., et al. 2002. Leukemia 16, 299.