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219012 Caspase-3 Inhibitor VII - CAS 745046-84-8 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-(4-Methyl-8-(morpholin-4-ylsulfonyl)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-c]quinolin-2-yl)ethyl acetate

Primary Target: capase-3
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
745046-84-8C₂₀H₂₁N₃O₇S
Description
Overview

This product has been discontinued.



A cell-permeable, non-peptidyl pyrroloquinoline compound that acts as a potent, reversible, and non-competitive inhibitor of caspase-3 (IC50 = 23 nM) with 10-100-fold greater selectivity. Shown to display higher anti-apoptotic activity than Z-VAD-FMK (Cat. No. 627610) in a model of Staurosporine- (Cat. No. 569397) induced apoptosis in human Jurkat T cells.
Catalogue Number219012
Brand Family Calbiochem®
Synonyms2-(4-Methyl-8-(morpholin-4-ylsulfonyl)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-c]quinolin-2-yl)ethyl acetate
References
ReferencesKravchenko, D.V., et al. 2005. J. Med. Chem. 48, 3680.
Product Information
CAS number745046-84-8
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₂₀H₂₁N₃O₇S
Chemical formulaC₂₀H₂₁N₃O₇S
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetcapase-3
Primary Target IC<sub>50</sub>23 nM
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
219012 0

Documentation

Caspase-3 Inhibitor VII - CAS 745046-84-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Caspase-3 Inhibitor VII - CAS 745046-84-8 - Calbiochem Certificates of Analysis

TitleLot Number
219012

References

Reference overview
Kravchenko, D.V., et al. 2005. J. Med. Chem. 48, 3680.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-April-2011 RFH
Synonyms2-(4-Methyl-8-(morpholin-4-ylsulfonyl)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-c]quinolin-2-yl)ethyl acetate
DescriptionA cell-permeable, non-peptidyl pyrroloquinoline compound that acts as a potent, reversible, and non-competitive inhibitor of caspase-3 (IC50 = 23 nM) with larger than 10-fold greater selectivity towards caspase-3 than caspases-1, -2, and -4 through -10. Shown to display higher anti-apoptotic activity than Z-VAD-FMK (Cat. No. 627610) in preventing Staurosporine- (Cat. No. 569397) induced apoptosis in human Jurkat T cells.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number745046-84-8
Chemical formulaC₂₀H₂₁N₃O₇S
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesKravchenko, D.V., et al. 2005. J. Med. Chem. 48, 3680.