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211875 Captopril - CAS 62571-86-2 - Calbiochem

Captopril - CAS 62571-86-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: [2S]-1-[3-Mercapto-2-methylpropionyl]-L-proline, SQ-14225

Primary Target: ACE
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
62571-86-2C₉H₁₅NO₃S
Description
Overview

This product has been discontinued.



An antihypertensive agent that competitively inhibits angiotensin-converting enzyme (ACE; IC50= 23-35 nM) and acts as a reversible and competitive inhibitor of LTA4 hydrolase (IC50 = 11 µM). Inhibits angiogenesis and slows the growth of experimental tumors in rats. Reported to inhibit apoptosis in human lung epithelial cells (IC50 = ~ 320 nM).
Catalogue Number211875
Brand Family Calbiochem®
Synonyms[2S]-1-[3-Mercapto-2-methylpropionyl]-L-proline, SQ-14225
References
ReferencesUhal, B.D., et al. 1998. Am. J. Physiol. 275, L1013.
Volpert, O.V., et al. 1996. J. Clin. Invest. 98, 671.
Voors, A.A., et al. 1995. J. Cardiovasc. Risk 2, 413.
Orning, L., et al. 1991. J. Biol. Chem. 266, 16507.
Kostis, J. 1988. Am. Heart J. 116, 1591.
Product Information
CAS number62571-86-2
ATP CompetitiveN
FormWhite to off-white solid
Hill FormulaC₉H₁₅NO₃S
Chemical formulaC₉H₁₅NO₃S
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetACE
Primary Target IC<sub>50</sub>23-35 nM against angiotensin-converting enzyme (ACE); 11 µM against LTA4 hydrolase; ~ 320 nM inhibiting apoptosis in human lung epithelial cells
Purity≥98% by titration
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSUY0550000
Safety Information
R PhraseR: 63-43

Possible risk of harm to the unborn child.
May cause sensitization by skin contact.
S PhraseS: 22-36

Do not breathe dust.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
211875 0

Documentation

Captopril - CAS 62571-86-2 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Captopril - CAS 62571-86-2 - Calbiochem Certificates of Analysis

TitleLot Number
211875

References

Reference overview
Uhal, B.D., et al. 1998. Am. J. Physiol. 275, L1013.
Volpert, O.V., et al. 1996. J. Clin. Invest. 98, 671.
Voors, A.A., et al. 1995. J. Cardiovasc. Risk 2, 413.
Orning, L., et al. 1991. J. Biol. Chem. 266, 16507.
Kostis, J. 1988. Am. Heart J. 116, 1591.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-April-2008 RFH
Synonyms[2S]-1-[3-Mercapto-2-methylpropionyl]-L-proline, SQ-14225
DescriptionAn antihypertensive agent. Reversible and competitive inhibitor of LTA4 hydrolase (IC50 = 11 µM). Also a competitive inhibitor of angiotensin-converting enzyme (ACE). Inhibits angiogenesis and slows the growth of experimental tumors in rats.
FormWhite to off-white solid
CAS number62571-86-2
RTECSUY0550000
Chemical formulaC₉H₁₅NO₃S
Structure formulaStructure formula
Purity≥98% by titration
SolubilityH₂O (1 mg/ml)
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Carcinogenic / Teratogenic
Merck USA index14, 1774
ReferencesUhal, B.D., et al. 1998. Am. J. Physiol. 275, L1013.
Volpert, O.V., et al. 1996. J. Clin. Invest. 98, 671.
Voors, A.A., et al. 1995. J. Cardiovasc. Risk 2, 413.
Orning, L., et al. 1991. J. Biol. Chem. 266, 16507.
Kostis, J. 1988. Am. Heart J. 116, 1591.