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208734 Calmodulin Binding Domain - CAS 115044-69-4 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Calmodulin antagonist, CaM kinase II 290-309

Primary Target: Calmodulin dependent Protein Kinase-2
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
115044-69-4C₁₀₃H₁₈₅N₃₁O₂₄S
Description
Overview

This product has been discontinued.



Potent calmodulin antagonist. Inhibits activation of calmodulin-dependent protein kinase II (IC50 = 52 nM). Interacts with the catalytic core of CaM kinase II as a pseudosubstrate.
Catalogue Number208734
Brand Family Calbiochem®
SynonymsCalmodulin antagonist, CaM kinase II 290-309
References
ReferencesJames, P., et al. 1995. Trends Biochem. Sci. 20, 38.
Mukherji, S., and Soderling, T.R. 1995. J. Biol. Chem. 270, 14062.
Yazawa, M., et al. 1992. Biochemistry 31, 3171.
Payne, M.E., et al. 1988. J. Biol. Chem. 263, 7190.
Product Information
CAS number115044-69-4
ATP CompetitiveN
FormWhite lyophilized solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₁₀₃H₁₈₅N₃₁O₂₄S
Chemical formulaC₁₀₃H₁₈₅N₃₁O₂₄S
Hygroscopic Hygroscopic
ReversibleN
Sold on the basis of peptide contentY
Quality LevelMQ100
Applications
Biological Information
Primary TargetCalmodulin dependent Protein Kinase-2
Primary Target IC<sub>50</sub>52 nM against calmodulin-dependent protein kinase II
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Peptide ContentY
Peptide SequenceH-Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-Ala-Ile-Leu-Thr-Thr-Met-Leu-Ala-OH
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 1 year at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
208734 0

Documentation

Calmodulin Binding Domain - CAS 115044-69-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Calmodulin Binding Domain - CAS 115044-69-4 - Calbiochem Certificates of Analysis

TitleLot Number
208734

References

Reference overview
James, P., et al. 1995. Trends Biochem. Sci. 20, 38.
Mukherji, S., and Soderling, T.R. 1995. J. Biol. Chem. 270, 14062.
Yazawa, M., et al. 1992. Biochemistry 31, 3171.
Payne, M.E., et al. 1988. J. Biol. Chem. 263, 7190.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-May-2008 RFH
SynonymsCalmodulin antagonist, CaM kinase II 290-309
DescriptionA potent calmodulin antagonist that inhibits Ca2+/calmodulin-dependent protein kinase II (IC50 = 52 nM) and Ca2+/calmodulin-dependent phosphodiesterase (IC50 = 1.1 nM).
FormWhite lyophilized solid
FormulationSupplied as a trifluoroacetate salt.
CAS number115044-69-4
Chemical formulaC₁₀₃H₁₈₅N₃₁O₂₄S
Peptide SequenceH-Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-Ala-Ile-Leu-Thr-Thr-Met-Leu-Ala-OH
Purity≥95% by HPLC
SolubilityH₂O
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 1 year at -20°C.
Toxicity Standard Handling
ReferencesJames, P., et al. 1995. Trends Biochem. Sci. 20, 38.
Mukherji, S., and Soderling, T.R. 1995. J. Biol. Chem. 270, 14062.
Yazawa, M., et al. 1992. Biochemistry 31, 3171.
Payne, M.E., et al. 1988. J. Biol. Chem. 263, 7190.