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203890 CRAC Channel Inhibitor, BTP2 - CAS 223499-30-7 - Calbiochem

CRAC Channel Inhibitor, BTP2, CAS 223499-30-7, is a cell-permeable, potent blocker of Stim1 and Orai1-coupled Ca2+ release-activated Ca2+ channel-mediated SOCE in RBL-2H3 cells (IC50 = 590 n

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Synonyms: [N-{4-[3,5-bis(Trifluoromethyl)-1H-pyrazol-1-yl]phenyl}-4-methyl-1,2,3-thiadiazole-5-carboxamide], TPRC3 Channel Inhibitor II, Pyr2

Primary Target: CRAC Channel
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203890
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Overview

Key Spec Table

CAS #Empirical Formula
223499-30-7C₁₅H₉F₆N₅OS

Products

Catalogue NumberPackaging Qty/Pack
203890-5MG Plastic ampoule 5 mg
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Description
OverviewA cell-permeable pyrazole that acts as a more potent blocker of Stim1 and Orai1-coupled CRAC (Ca2+ release-activated Ca2+) channel-mediated SOCE (store-operated Ca2+ entry) in RBL-2H3 cells (IC50 = 590 nM by Fura-2; peak current density pA/pF = -1.13 and -7.50, respectively, with or without 3 µM BTP2/Pyr2 by whole cell clamp) than the transient receptor potential cation channel TRPC3-mediated ROCE (receptor-operated Ca2+ entry) inTRPC3-expressing HEK293 cells (IC50 = 4.21 µM by Fura-2; pA/pF = -1.54 and -18.50, respectively, with or without 3 µM BTP2/Pyr2). A great complement to Pyr 3 (Cat. No. 648490), Pyr6, and Pyr10 in Ca2+ signaling studies.
Catalogue Number203890
Brand Family Calbiochem®
Synonyms[N-{4-[3,5-bis(Trifluoromethyl)-1H-pyrazol-1-yl]phenyl}-4-methyl-1,2,3-thiadiazole-5-carboxamide], TPRC3 Channel Inhibitor II, Pyr2
References
ReferencesSchleifier, H., et al. 2012. Br J Pharmacol In Press
Yonetoku, Y., et al. 2006. Bioorg. Med. Chem. 14, 5370.
Yonetoku, Y., et al. 2006. Bioorg. Med. Chem. 14, 4750.
Zitt, C., et al. 2004. J. Biol. Chem. 279, 12927.
Trevillyan, J.M., et al. 2001. J. Biol. Chem. 276, 48118.
Djuric, S.W., et al. 2000. J. Med. Chem. 43, 2975.
Product Information
CAS number223499-30-7
ATP CompetitiveN
FormSolid
Hill FormulaC₁₅H₉F₆N₅OS
Chemical formulaC₁₅H₉F₆N₅OS
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationCRAC Channel Inhibitor, BTP2, CAS 223499-30-7, is a cell-permeable, potent blocker of Stim1 and Orai1-coupled Ca2+ release-activated Ca2+ channel-mediated SOCE in RBL-2H3 cells (IC50 = 590 nM).
Biological Information
Primary TargetCRAC Channel
Primary Target IC<sub>50</sub>590 nM by Fura-2
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
203890-5MG 04055977204070