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220005 CGP-37157 - CAS 75450-34-9 - Calbiochem

A cell-permeable benzothiazepine derivative of clonazepam that acts as a specific and potent inhibitor of the mitochondrial Na+/Ca2+ exchanger (IC₅₀ = 360 nM).

CGP-37157 - CAS 75450-34-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one

Primary Target: Mitochondrial Na+/Ca2+ exchanger
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
75450-34-9C₁₅H₁₁Cl₂NOS
Description
OverviewA cell-permeable benzothiazepine derivative of clonazepam that acts as a specific and potent inhibitor of the mitochondrial Na+/Ca2+ exchanger (IC50 = 360 nM). Enhances the export of Ca2+ from isolated mitochondria. Also reported to directly inhibit voltage-gated Ca2+ channels.
Catalogue Number220005
Brand Family Calbiochem®
Synonyms7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one
References
ReferencesJornot, L., et al. 1999. J. Cell Sci. 112, 1013.
Babcock, D.F., et al. 1997. J. Cell Biol. 136, 833.
Baron. K.T., and Thayer, S.A. 1997. Eur. J. Pharmacol. 340, 295.
Griffiths, E.J., et al. 1997. Cell Calcium 21, 321.
White, R.J., and Reynolds, I.J. 1996, J. Neurosci. 16, 5688.
Cox, D.A., et al. 1993. J. Cardivasc. Pharmacol. 21, 595.
Cox, D.A., and Matlib, M.A. 1993. J. Biol. Chem. 268, 938.
Product Information
CAS number75450-34-9
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₅H₁₁Cl₂NOS
Chemical formulaC₁₅H₁₁Cl₂NOS
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetMitochondrial Na+/Ca2+ exchanger
Primary Target IC<sub>50</sub>360 nM against mitochondrial Na+/Ca2+ exchanger
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
220005 0

Documentation

CGP-37157 - CAS 75450-34-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

CGP-37157 - CAS 75450-34-9 - Calbiochem Certificates of Analysis

TitleLot Number
220005

References

Reference overview
Jornot, L., et al. 1999. J. Cell Sci. 112, 1013.
Babcock, D.F., et al. 1997. J. Cell Biol. 136, 833.
Baron. K.T., and Thayer, S.A. 1997. Eur. J. Pharmacol. 340, 295.
Griffiths, E.J., et al. 1997. Cell Calcium 21, 321.
White, R.J., and Reynolds, I.J. 1996, J. Neurosci. 16, 5688.
Cox, D.A., et al. 1993. J. Cardivasc. Pharmacol. 21, 595.
Cox, D.A., and Matlib, M.A. 1993. J. Biol. Chem. 268, 938.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-May-2013 JSW
Synonyms7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one
DescriptionA cell-permeable benzothiazepine derivative of clonazepam that acts as a specific and potent inhibitor of the mitochondrial Na+/Ca2+ exchanger (IC50 = 360 nM). Enhances the export of Ca2+ from isolated mitochondria. Also reported to directly inhibit voltage-gated Ca2+ channels.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number75450-34-9
Chemical formulaC₁₅H₁₁Cl₂NOS
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (5 mg/ml). Dilute in Ca2+-free buffer just prior to use.
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesJornot, L., et al. 1999. J. Cell Sci. 112, 1013.
Babcock, D.F., et al. 1997. J. Cell Biol. 136, 833.
Baron. K.T., and Thayer, S.A. 1997. Eur. J. Pharmacol. 340, 295.
Griffiths, E.J., et al. 1997. Cell Calcium 21, 321.
White, R.J., and Reynolds, I.J. 1996, J. Neurosci. 16, 5688.
Cox, D.A., et al. 1993. J. Cardivasc. Pharmacol. 21, 595.
Cox, D.A., and Matlib, M.A. 1993. J. Biol. Chem. 268, 938.