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217693 CDC25 Phosphatase Inhibitor III, BN82685, Benzoate Salt

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-(2-Dimethylamino-ethylamino)-2-methyl-benzothiazole-4,7-dione, benzoate

217693
  
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Overview

Replacement Information
Description
Overview

This product has been discontinued.

We are offering CDC25 Phosphatase Inhibitor I, BN82002 (Cat. No. 217691) and CDC25 Phosphatase Inhibitor II, NSC 663284 (Cat. No. 217692) as possible alternative. Please read the alternative product documentation carefully and contact technical service if you need additional information.





A cell-permeable dioxobenzothiazole compound that acts as a potent, selective, and irreversible inhibitor of CDC25 family phosphatases (IC50 = 109, 160, 249, 201, and 117 nM for 25A, 25B2, 25B3, 25C, and 25C-cat, respectively). Shown to block CDC25-dependent cellular dephosphorylation, mitosis, cell cycle progression, and proliferation in vitro and inhibit tumor growth in mice in vivo.
Catalogue Number217693
Brand Family Calbiochem®
Synonyms5-(2-Dimethylamino-ethylamino)-2-methyl-benzothiazole-4,7-dione, benzoate
References
ReferencesCazales, M., et al. 2007. Mol. Cancer. Ther. 6, 318. Lavergne, O., et al. 2005. Bioorg. Med. Chem. Lett. 16, 171. Brezak, M.C., et al. 2005. Mol. Cancer Ther. 4, 1378.
Product Information
FormRed solid
Hill FormulaC₁₂H₁₅N₃O₂S • C₇H₆O₂
Chemical formulaC₁₂H₁₅N₃O₂S • C₇H₆O₂
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
217693 0

Documentation

CDC25 Phosphatase Inhibitor III, BN82685, Benzoate Salt Certificates of Analysis

TitleLot Number
217693

References

Reference overview
Cazales, M., et al. 2007. Mol. Cancer. Ther. 6, 318. Lavergne, O., et al. 2005. Bioorg. Med. Chem. Lett. 16, 171. Brezak, M.C., et al. 2005. Mol. Cancer Ther. 4, 1378.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision03-June-2008 RFH
Synonyms5-(2-Dimethylamino-ethylamino)-2-methyl-benzothiazole-4,7-dione, benzoate
DescriptionA cell-permeable dioxobenzothiazole compound that acts as a potent, selective, and irreversible inhibitor of CDC25 family phosphatases (IC50 = 109, 160, 249, 201, and 117 nM for 25A, 25B2, 25B3, 25C, and 25C-cat, respectively). Shown to block CDC25-dependent cellular dephosphorylation, mitosis, cell cycle progression, and proliferation in vitro and inhibit tumor growth in mice in vivo.
FormRed solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₂H₁₅N₃O₂S • C₇H₆O₂
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (5 mg/ml). The use of fresh DMSO is strongly recommended for reconstitution.
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesCazales, M., et al. 2007. Mol. Cancer. Ther. 6, 318. Lavergne, O., et al. 2005. Bioorg. Med. Chem. Lett. 16, 171. Brezak, M.C., et al. 2005. Mol. Cancer Ther. 4, 1378.