Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

SCT077 BioTracker TiNIR HMOX2 Live Cell Dye

Near-Infrared probe for detection and isolation of HMOX2 expressing tumor initiating cells.

View Products on Sigmaaldrich.com
SCT077
1 mg  
Purchase on Sigma-Aldrich

Overview

Replacement Information
Description
Catalogue NumberSCT077
DescriptionBioTracker TiNIR HMOX2 Live Cell Dye
OverviewIncreasing evidence suggests that a small population of tumor initiating cells (TIC) or cancer stem cells (CSC) are responsible for tumorigenesis and resistance to conventional anti-cancer therapies. Heme oxygenase 2 (HMOX2) has recently been identified as a novel biomarker for tumor initiating cells (1).

BioTracker TiNIR HMOX2 Live Cell Dye is a near-infrared (NIR) fluorescent probe for the detection and isolation of HMOX2 expressing tumor initiating cells. At low concentrations or a single injection of high concentration, TiNIR (tumor initiating cell probe with near infrared) is useful for the isolation of TIC in vitro and in vivo visualization in tumor model animals, respectively. At high concentrations or repeated treatments, TiNIR has been shown to inhibit the function of HMOX2 and induce tumor cell death by accumulating ROS in cancer cells (1).

Spectral Properties
Absorbance: 805 nm
Emission: 825 nm

Reference:
1. Kim, J. J., Lee, Y. A., Su, D., Lee, J., Park, S. J., Kim, B., ... & Chang, Y. T. (2019). A near-infrared probe tracks and treats lung tumor initiating cells by targeting HMOX2. Journal of the American Chemical Society, 141(37), 14673-14686.
Alternate Names
  • Live Cell Imaging Probe
References
Product Information
Detection methodFluorescence
PresentationLyophilized. Green solid.
Applications
ApplicationNear-Infrared probe for detection and isolation of HMOX2 expressing tumor initiating cells.
Key Applications
  • Cell Based Assays
Application NotesLive cell fluorescent imaging
Biological Information
Molecular Weight797.82
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssurancePurity ≥ 98% confirmed by HPLC. Identification confirmed by HNMR, LC-MS, and elemental analysis.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStore at -20°C, desiccate and protect from light
Note: Centrifuge vial briefly to collect contents at bottom of vial before opening
Packaging Information
Material Size1 mg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
SCT077 04061841827931