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197331 Bcl-2 Inhibitor II, YC137 - CAS 810659-53-1 - Calbiochem

The Bcl-2 Inhibitor II, YC137, also referenced under CAS 810659-53-1, controls the biological activity of Bcl-2. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-Methoxycarbonylamino-4-methylsulfanyl-butyric acid, 4-(4,9-dioxo-4,9-dihydronaphtho[2,3-d]thiazol-2-ylamino)-phenyl ester

Primary Target: Bcl-2
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197331
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
810659-53-1C₂₄H₂₁N₃O₆S₂

Products

Catalogue NumberPackaging Qty/Pack
197331-5MG Glass bottle 5 mg
Description
OverviewA cell-permeable naphthoquinone compound that selectively induces apoptosis of Bcl-2-overexpressing cells (< 300 nM in MDA-MB435B breast cancer cells) with little effect on a variety of primary cells, and Bcl-xL-dependent cells, even at a concentration of 5 µM. Preferentially binds Bcl-2 (Ki = 1.3 µM) and disrupts its interaction with Bid BH3, thereby blocking the anti-apoptotic activity of Bcl-2. Shown to induce the release of cytochrome c from mitochondria and activate caspase-9.
Catalogue Number197331
Brand Family Calbiochem®
Synonyms2-Methoxycarbonylamino-4-methylsulfanyl-butyric acid, 4-(4,9-dioxo-4,9-dihydronaphtho[2,3-d]thiazol-2-ylamino)-phenyl ester
References
ReferencesReal, P.J., et al. 2004. Cancer Res. 64, 7947.
Product Information
CAS number810659-53-1
ATP CompetitiveN
FormRed solid
Hill FormulaC₂₄H₂₁N₃O₆S₂
Chemical formulaC₂₄H₂₁N₃O₆S₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetBcl-2
Primary Target K<sub>i</sub>1.3 µM in binding Bcl-2
Purity≥90% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Carcinogenic / Teratogenic
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
197331-5MG 04055977206081

Documentation

Bcl-2 Inhibitor II, YC137 - CAS 810659-53-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Bcl-2 Inhibitor II, YC137 - CAS 810659-53-1 - Calbiochem Certificates of Analysis

TitleLot Number
197331

References

Reference overview
Real, P.J., et al. 2004. Cancer Res. 64, 7947.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision31-March-2011 RFH
Synonyms2-Methoxycarbonylamino-4-methylsulfanyl-butyric acid, 4-(4,9-dioxo-4,9-dihydronaphtho[2,3-d]thiazol-2-ylamino)-phenyl ester
DescriptionA cell-permeable molecule that targets the BH3•domain interaction and selectively induces apoptosis in Bcl-2-overexpressing cells (<300 nM in MDA-MB435B breast cancer cells). Exhibits little effect on a variety of primary cells and Bcl-xL-dependent cells, even at a concentrations as high as 5 µM. Inhibits the binding of Bid BH3 to Bcl-2 thereby blocking the anti-apoptotic activity of Bcl-2.
FormRed solid
Intert gas (Yes/No) Packaged under inert gas
CAS number810659-53-1
Chemical formulaC₂₄H₂₁N₃O₆S₂
Structure formulaStructure formula
Purity≥90% by HPLC
SolubilityDMSO (5 mg/ml) or Ethanol (5 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Carcinogenic / Teratogenic
ReferencesReal, P.J., et al. 2004. Cancer Res. 64, 7947.