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197900 BEC, Hydrochloride - Calbiochem

BEC, Hydrochloride, CAS 63107-40-4, is a slow-binding, competitive transition state inhibitor of arginases I and II (Ki = 310 nM for human type II arginase). Does not inhibit nitric oxide synthase.

BEC, Hydrochloride - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (S)-(2-Boronoethyl)-L-cysteine, HCI)

Primary Target: arginase 1, arginase 2
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₅H₁₂BNO₄S · HCl

Products

Catalogue NumberPackaging Qty/Pack
197900-5MG Plastic ampoule 5 mg
Description
OverviewA boronic acid-based arginine analog that acts as a slow-binding, competitive transition state inhibitor of arginases I and II (Ki = 310 nM for human recombinant type II arginase, pH 7.5). BEC does not inhibit nitric oxide synthase (NOS). Causes significant enhancement of NO-dependent smooth muscle relaxation in human penile corpus cavernosum tissue.
Catalogue Number197900
Brand Family Calbiochem®
Synonyms(S)-(2-Boronoethyl)-L-cysteine, HCI)
References
ReferencesColleluori, D.M., and Ash, D.E. 2001. Biochemistry 40, 9356.
Kim, N.N., et al. 2001. Biochemistry 40, 2678.
Product Information
ATP CompetitiveN
FormWhite solid
Hill FormulaC₅H₁₂BNO₄S · HCl
Chemical formulaC₅H₁₂BNO₄S · HCl
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationBEC, Hydrochloride, CAS 63107-40-4, is a slow-binding, competitive transition state inhibitor of arginases I and II (Ki = 310 nM for human type II arginase). Does not inhibit nitric oxide synthase.
Biological Information
Primary Targetarginase 1, arginase 2
Primary Target K<sub>i</sub>310 nM for human recombinant type II arginase, pH 7.5
Purity≥97% by NMR
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 20/21/22

Harmful by inhalation, in contact with skin and if swallowed.
S PhraseS: 36

Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot, flush with nitrogen, and freeze at -20°C. Stock solutions are stable for up to 1 month at -20°C. After thawing, discard any unused portion.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
197900-5MG 07790788048273

Documentation

BEC, Hydrochloride - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

BEC, Hydrochloride - Calbiochem Certificates of Analysis

TitleLot Number
197900

References

Reference overview
Colleluori, D.M., and Ash, D.E. 2001. Biochemistry 40, 9356.
Kim, N.N., et al. 2001. Biochemistry 40, 2678.

Brochure

Title
Pathways and Biomarkers of Oxidative Stress
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision27-September-2010 RFH
Synonyms(S)-(2-Boronoethyl)-L-cysteine, HCI)
DescriptionA boronic acid based arginine analog that acts as a selective, slow- binding, reversible, competitive transition state inhibitor of arginase type I and II (Ki = 310 nM for human recombinant type II arginase, pH 7.5). Shown to enhance nitric oxide-dependent relaxation of human penile corpus cavernosum smooth muscle by inhibiting the activity of arginase. Does not inhibit the activity of nitric oxide synthase (NOS) and may serve as a valuable reagent to probe the physiological relationship between arginase and NOS.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₅H₁₂BNO₄S · HCl
Structure formulaStructure formula
Purity≥97% by NMR
SolubilityH₂O (10 mg/ml)
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot, flush with nitrogen, and freeze at -20°C. Stock solutions are stable for up to 1 month at -20°C. After thawing, discard any unused portion.
Toxicity Harmful
ReferencesColleluori, D.M., and Ash, D.E. 2001. Biochemistry 40, 9356.
Kim, N.N., et al. 2001. Biochemistry 40, 2678.