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533796 Asparagine Endopeptidase Inhibitor, AENK

A specific, competitive inhibitor of the asparagine endopeptidase that suppresses tau cleavage and tetanus toxin antigen processing.

Asparagine Endopeptidase Inhibitor, AENK MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Fmoc-Ala-Glu-Asn-Lys-NH2, Asparagine Endopeptidase Inhibitor, AENK, AEP Inhibitor, AENK

Primary Target: AEP
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Overview

Key Spec Table

Empirical Formula
C₃₃H₄₃N₇O₉
Description
OverviewAn amino and carboxy-terminal blocked tetra peptide that acts as a specific, competitive inhibitor of the protease activity of asparagine endopeptidase (AEP), an enzyme that cleaves substrates on the C-terminal side of asparagine. Believed to act as a competitive substrate that itself is hydrolyzed by AEP. Shown to block processing of tetanus toxin antigen (TTCF) in vitro (~1 mg/ml) and retard TTCF presentation to T cells in vivo. Does not affect the cleavage of cathepsin B/L and cathepsin S substrates. Shown to selectively and completely suppress tau cleavage by AEP (~ 1 mg/ml).

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
Catalogue Number533796
Brand Family Calbiochem®
SynonymsFmoc-Ala-Glu-Asn-Lys-NH2, Asparagine Endopeptidase Inhibitor, AENK, AEP Inhibitor, AENK
References
ReferencesZhang, Z., et al. 1999. Nat. Med. 20, 1254.
Monoury, B., et al. 1998. Nat. 396, 695.
Product Information
FormWhite solid
FormulationSupplied as a TFA salt.
Hill FormulaC₃₃H₄₃N₇O₉
Chemical formulaC₃₃H₄₃N₇O₉
ReversibleY
Quality LevelMQ100
Biological Information
Primary TargetAEP
Purity≥98% by HPLC
Physicochemical Information
Peptide SequenceFmoc-Ala-Glu-Asn-Lys-NH2
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
533796 0