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616399 Aprotinin, Bovine Lung, Solution - CAS 9087-70-1 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Kallikrein Inactivator

Primary Target: chymotrypsin
616399
  
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Overview

Replacement Information

Key Spec Table

CAS #
9087-70-1
Description
Overview

This product has been discontinued.



Competitive reversible inhibitor of proteolytic and esterolytic activity. A relatively heat- and acid-stable serine protease inhibitor. Forms a tight complex, blocking the active site of the enzyme. Effective at concentrations equimolar with protease. Inhibits several proteases, including coagulation factors in the prephase of blood clotting, tissue and leukocytic proteinases, chymotrypsin, trypsin (Kd = 5 x 10-14 M), plasmin (Kd = 2.3 x 10-10 M), and kallikrein (Kd = 1 x 10-7 M). Proteases not inhibited by aprotinin include Factor Xa, thrombin, pepsin, papain, and carboxypeptidases A and B. Useful in protein purification and for extending the life of cells in culture by preventing proteolytic damage.
Note: 1 KU = 1000 K.I.U.
Catalogue Number616399
Brand Family Calbiochem®
SynonymsKallikrein Inactivator
References
ReferencesAzougagh Oualane, F., et al. 1992. Thromb. Res. 68, 185.
Anderson, L.O., et al. 1986. Proc. Natl. Acad. Sci. USA 83, 2979.
Kruithof, W.L., et al. 1986. Biochem. J. 226, 631.
Product Information
CAS number9087-70-1
Activity≥6500 KIU/ml
Unit of DefinitionOne Kallikrein Inhibitory Unit (KIU) is identical to the quantity of protease inhibitor that has the ability to inhibit two kallikrein units by 50% under optimal conditions
ATP CompetitiveN
FormLiquid
FormulationIn isotonic NaCl, aseptically filled.
PI10.5
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary Targetchymotrypsin
Primary Target IC<sub>50</sub>Kd = 5 x 10-14 M, 2.3 x 10-10 M, 1 x 10-7 M against trypsin, plasmin, and kallikrein, respectively
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSYN5080000
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Do not freeze Ok to freeze
Canadian export regulations Due to the country and/or U.S. state of origin of the animal material used in this product, this product may not be exported to Canada.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
616399 0

Documentation

Aprotinin, Bovine Lung, Solution - CAS 9087-70-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Aprotinin, Bovine Lung, Solution - CAS 9087-70-1 - Calbiochem Certificates of Analysis

TitleLot Number
616399

References

Reference overview
Azougagh Oualane, F., et al. 1992. Thromb. Res. 68, 185.
Anderson, L.O., et al. 1986. Proc. Natl. Acad. Sci. USA 83, 2979.
Kruithof, W.L., et al. 1986. Biochem. J. 226, 631.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-May-2010 JSW
SynonymsKallikrein Inactivator
DescriptionCompetitive reversible inhibitor of proteolytic and esterolytic activity. A relatively heat- and acid-stable serine protease inhibitor. Forms a tight complex, blocking the active site of the enzyme. Effective at concentrations equimolar with protease. Inhibits several proteases, including coagulation factors in the prephase of blood clotting, tissue and leukocytic proteinases, chymotrypsin, trypsin (Kd = 5 x 10-14 M), plasmin (Kd = 2.3 x 10-10 M), and kallikrein (Kd = 1 x 10-7 M). Proteases not inhibited by aprotinin include Factor Xa, thrombin, pepsin, papain, and carboxypeptidases A and B. Useful in protein purification and for extending the life of cells in culture by preventing proteolytic damage.
FormLiquid
FormulationIn isotonic NaCl, aseptically filled.
CAS number9087-70-1
RTECSYN5080000
Activity≥6500 KIU/ml
Unit definitionOne Kallikrein Inhibitory Unit (KIU) is identical to the quantity of protease inhibitor that has the ability to inhibit two kallikrein units by 50% under optimal conditions
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Toxicity Standard Handling
Merck USA index14, 757
ReferencesAzougagh Oualane, F., et al. 1992. Thromb. Res. 68, 185.
Anderson, L.O., et al. 1986. Proc. Natl. Acad. Sci. USA 83, 2979.
Kruithof, W.L., et al. 1986. Biochem. J. 226, 631.