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07-806 Anti-phospho-c-Kit (Tyr568/Tyr570) Antibody

Anti-phospho-c-Kit (Tyr568/Tyr570) Antibody is an antibody against phospho-c-Kit (Tyr568/Tyr570) for use in WB.

Anti-phospho-c-Kit (Tyr568/Tyr570) Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Growth Factors & Receptors Gene Symbol: KIT, C-Kit, PBT, CD117, SCFR, c-kit UniProt Number: P10721
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWBRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue Number07-806
Brand Family Upstate
Trade Name
  • Upstate
DescriptionAnti-phospho-c-Kit (Tyr568/Tyr570) Antibody
Alternate Names
  • KIT
  • CD117
  • PBT
  • SCFR
  • v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
References
Product Information
FormatAffinity Purified
Quality LevelMQ100
Applications
ApplicationAnti-phospho-c-Kit (Tyr568/Tyr570) Antibody is an antibody against phospho-c-Kit (Tyr568/Tyr570) for use in WB.
Key Applications
  • Western Blotting
Biological Information
ImmunogenPeptide corresponding to amino acid region encompassing the human, mouse, rat, chicken, cow and dog. phospho-c-Kit (Tyr568/ Tyr570).
HostRabbit
SpecificityRecognizes phospho-c-Kit (Tyr568/ Tyr570)
IsotypeIgG
Species Reactivity
  • Human
Species Reactivity NotePredicted to cross-react with Mouse and Rat based on complete sequence homology.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThis gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene Symbol
  • KIT
  • C-Kit
  • PBT
  • CD117
  • SCFR
  • c-kit
Modifications
  • Phosphorylation
Purification MethodImmunoAffinity Purified
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P10721 # This is the receptor for stem cell factor (mast cell growth factor). It has a tyrosine-protein kinase activity. Binding of the ligands leads to the autophosphorylation of KIT and its association with substrates such as phosphatidylinositol 3-kinase (Pi3K).
SIZE: 976 amino acids; 109865 Da
SUBUNIT: Interacts with APS. Interacts with the tenth PDZ domain of MPDZ.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
DISEASE: SwissProt: P10721 # Defects in KIT are a cause of piebaldism [MIM:172800]. Piebaldism is an autosomal dominant genetic developmental abnormality of pigmentation characterized by congenital patches of white skin and hair that lack melanocytes. & Defects in KIT are a cause of gastrointestinal stromal tumor (GIST) [MIM:606764]. & Defects in KIT have been associated with testicular tumors [MIM:273300]. It includes germ cell tumor (GCT) or testicular germ cell tumor (TGCT).
SIMILARITY: SwissProt: P10721 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. & Contains 5 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated by immunoblot.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
07-806 04053252677540

Documentation

Anti-phospho-c-Kit (Tyr568/Tyr570) Antibody SDS

Title

Safety Data Sheet (SDS) 

Anti-phospho-c-Kit (Tyr568/Tyr570) Antibody Certificates of Analysis

TitleLot Number
Anti-phospho-c-Kit (Tyr568/Tyr570) - 2152455 2152455
Anti-phospho-c-Kit (Tyr568/Tyr570) (Affinity purified Rabbit polyclonal IgG) - 2386933 2386933
Anti-phospho-c-Kit (Tyr568/Tyr570) (Affinity purified Rabbit polyclonal IgG) 3093138
Anti-phospho-c-Kit (Tyr568/Tyr570) (Affinity purified Rabbit polyclonal IgG) 2969383
Anti-phospho-c-Kit (Tyr568/Tyr570) (Affinity purified Rabbit polyclonal IgG) - 2280199 2280199
Anti-phospho-c-Kit (Tyr568/Tyr570) (Affinity purified Rabbit polyclonal IgG) - DAM1408789 DAM1408789
Anti-phospho-c-Kit (Tyr568/Tyr570) - 0608038400 0608038400
Anti-phospho-c-Kit (Tyr568/Tyr570) - 3907841 3907841
Anti-phospho-c-Kit (Tyr568/Tyr570) - 3949240 3949240
Anti-phospho-c-Kit (Tyr568/Tyr570) - 4010047 4010047
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References

Reference overviewPub Med ID
Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes
Price, D J, et al
J Biol Chem, 272:5915-20 (1997)  1997

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