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MAB5504A4 Anti-Vesicular Glutamate Transporter 2 Antibody, Alexa Fluor® 488

This Anti-Vesicular Glutamate Transporter 2 Antibody, Alexa Fluor 488 is validated for use in IH for the detection of Vesicular Glutamate Transporter 2.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience Gene Symbol: Slc17a6, Dnpi, Vglut2, VGLUT2 UniProt Number: Q9JI12
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MAB5504A4
100 µL  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
M, R, HIHCMAlexaFluor®488Monoclonal Antibody
Description
Catalogue NumberMAB5504A4
DescriptionAnti-Vesicular Glutamate Transporter 2 Antibody, Alexa Fluor® 488
Alternate Names
  • Vesicular glutamate transporter 2
  • VGluT2
  • Differentiation-associated BNPI
  • Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter
  • Solute carrier family 17 member 6
Background InformationVesicular Glutamate Transporter 2 (VGLUT2) is a sodium dependent inorganic phosphate cotransporter that is involved in the calcium dependent glutamate release from astrocytes. It is expressed in only a subset of neurons, localized to synaptic vesicles, at synapses exhibiting classical excitatory features. VGLUT2 mRNA is found in brain regions that lack VGLUT1, a related protein also displaying sodium dependent inorganic phosphate cotransporter activity.
Product Information
FormatAlexaFluor®488
Control
  • Adult mouse brain tissue
PresentationPurified mouse monoclonal IgG1 conjugated to Alexa Fluor® 488 in PBS with 0.1% sodium azide and 15 mg/mL BSA.
Quality LevelMQ100
Applications
ApplicationThis Anti-Vesicular Glutamate Transporter 2 Antibody, Alexa Fluor 488 is validated for use in IH for the detection of Vesicular Glutamate Transporter 2.
Key Applications
  • Immunohistochemistry
Biological Information
ImmunogenRecombinant protein from rat VGLUT2.
Clone8G9.2
HostMouse
IsotypeIgG1
Species Reactivity
  • Mouse
  • Rat
  • Human
Species Reactivity NoteDemonstrated to react with Mouse and Rat. Predicted to react with Human based on 100% sequence homology.
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Entrez Gene SummaryNa+-dependent inorganic phosphate cotransporter; involved in Ca2+-dependent glutamate release from astrocytes [RGD].
Gene Symbol
  • Slc17a6
  • Dnpi
  • Vglut2
  • VGLUT2
Purification MethodProtein A Purfied
UniProt Number
UniProt SummaryFUNCTION: Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also play a role in the endocrine glutamatergic system of other tissues such as pineal gland and pancreas. May also mediate the transport of inorganic phosphate.

SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Membrane; Multi-pass membrane protein (Potential). Cell junction, synapse, synaptosome.

TISSUE SPECIFICITY: Expressed in brain (at protein level). Expressed in brainstem, deep nuclei, septal nuclei, nuclei of the diagonal band, frontal cortex, hypothalamus, midbrain, parietal cortex and temporal cortex. Also expressed in pineal gland and islets of Langerhans.

SIMILARITY: Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily.

SIZE: 582 amino acids; 64392 Da
Molecular WeightThe unconjugated parent antibody (Cat. No. MAB5504) has an observed molecular weight at ~56 kDa.
Product Usage Statements
Quality AssuranceEvaluated by Immunohistochemistry in adult mouse brain tissue.

Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected Vesicular Glutamate Transporter 2 in adult mouse brain tissue.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
Packaging Information
Material Size100 µL
Global Trade Item Number
Catalogue Number GTIN
MAB5504A4 04053252421006