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MAB2511 Anti-VCAM-1 Antibody, clone P8B1

Anti-VCAM-1 Antibody, clone P8B1 detects level of VCAM-1 & has been published & validated.

Anti-VCAM-1 Antibody, clone P8B1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Cell Structure Research Sub-Category: Adhesion (CAMs) Gene Symbol: VCAM1, INCAM-100, MGC99561, CD106, DKFZp779G2333, L1CAM UniProt Number: P19320
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MAB2511
100 µg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HFUNCMPurifiedMonoclonal Antibody
Description
Catalogue NumberMAB2511
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-VCAM-1 Antibody, clone P8B1
Alternate Names
  • CD106
References
Product Information
FormatPurified
PresentationPurified immunoglobulin. Liquid in 0.2 M phosphate buffer to 0.25 M NaCl, pH 7.6 with 0.1% sodium azide. Caution: Sodium azide is toxic. See online MSDS.
Quality LevelMQ100
Applications
ApplicationAnti-VCAM-1 Antibody, clone P8B1 detects level of VCAM-1 & has been published & validated.
Key Applications
  • Affects Function
Application NotesFunction blocking

Optimal working dilutions must be determined by end user.
Biological Information
CloneP8B1
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostMouse
SpecificityMAB2511 recognizes the human VCAM-1 molecule. The antibody inhibits VLA-4 (integrin alpha4beta1) binding and recognizes a different epitope than that which is recognized by MAB2144 (P3C4 clone).
IsotypeIgG2b
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThis gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.
Gene Symbol
  • VCAM1
  • INCAM-100
  • MGC99561
  • CD106
  • DKFZp779G2333
  • L1CAM
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P19320 # Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
SIZE: 739 amino acids; 81276 Da
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue.
DOMAIN: SwissProt: P19320 Either the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion.
PTM: Sialoglycoprotein.
DISEASE:SwissProt: P19320 # May play an important role in the genesis of atherosclerosis and rheumatoid arthritis.
SIMILARITY: Contains 7 Ig-like C2-type (immunoglobulin-like) domains.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.

During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. For products with volumes of 200μL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container's cap.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
MAB2511 04053252578380

Documentation

Anti-VCAM-1 Antibody, clone P8B1 SDS

Title

Safety Data Sheet (SDS) 

Anti-VCAM-1 Antibody, clone P8B1 Certificates of Analysis

TitleLot Number
MOUSE ANTI HUMAN VCAM-1 MONOCLONAL ANTIBODY - 2441958 2441958
MOUSE ANTI HUMAN VCAM-1 MONOCLONAL ANTIBODY - 2145955 2145955
MOUSE ANTI HUMAN VCAM-1 - 3541901 3541901
MOUSE ANTI HUMAN VCAM-1 - 3598981 3598981
MOUSE ANTI HUMAN VCAM-1 - 3669258 3669258
MOUSE ANTI HUMAN VCAM-1 - 3734489 3734489
MOUSE ANTI HUMAN VCAM-1 - 3751174 3751174
MOUSE ANTI HUMAN VCAM-1 - 3836480 3836480
MOUSE ANTI HUMAN VCAM-1 - 4033759 4033759
MOUSE ANTI HUMAN VCAM-1 - 4035830 4035830
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Data Sheet

Title
Anti-VCAM-1, clone P8B1 - Data Sheet