Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

MABS1198 Anti-SPINK1 Antibody, clone 4D11.1

Anti-SPINK1, clone 4D11.1, Cat. No. MABS1198, is a highly specific mouse monoclonal antibody that targets SPINK1 and has been tested in Immunohistochemistry and Western Blotting.

Anti-SPINK1 Antibody, clone 4D11.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Gene Symbol: SPINK1, PCTT, PSTI, TCP UniProt Number: P00995
View Products on Sigmaaldrich.com
MABS1198
100 µL  
Purchase on Sigma-Aldrich

Special Offers

Overview

Replacement Information

Special Offers

100% Performance Guaranteed

Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, IH(P)MPurifiedMonoclonal Antibody
Description
Catalogue NumberMABS1198
DescriptionAnti-SPINK1 Antibody, clone 4D11.1
Alternate Names
  • Serine protease inhibitor Kazal-type 1
  • Pancreatic secretory trypsin inhibitor
  • TATI
  • Tumor-associated trypsin inhibitor
Background InformationSerine protease inhibitor Kazal-type 1 (UniProt P00995; also known as Pancreatic secretory trypsin inhibitor, TATI, Tumor-associated trypsin inhibitor) is encoded by the SPINK1 (also known as PCTT, PSTI, TCP) gene (Gene ID 6690) in human. Serine protease inhibitor Kazal-type 1 encoded by the human SPINK1 gene functions as an acute-phase protein (APP) in the pancreas. Produced initially in a 79-a.a. proform, the signal peptide (a.a. 1-23) is removed posttranslationally to yield the 56-a.a. (a.a. 24-79) mature protein. SPINK1 protein blocks premature activation of trypsinogen (inactive form of trypsin), thereby ensuring the integrity of acinar cells to prevent auto-digestion of the pancreas. SPINK1 is also reported to play a role in tissue repair, apoptosis, reproduction, and behave as a growth factor in other human organs. In addition, SPINK1 protein is known as tumor-associated trypsin inhibitor or TATI and current research activities are focused on the association of various cancers to deregulated SPINK1 activity.
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4) 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-SPINK1, clone 4D11.1, Cat. No. MABS1198, is a highly specific mouse monoclonal antibody that targets SPINK1 and has been tested in Immunohistochemistry and Western Blotting.
Key Applications
  • Western Blotting
  • Immunohistochemistry (Paraffin)
Application NotesImmunohistochemistry Analysis: A 1:250 dilution from a representative lot detected SPINK1 in human pancreas tissue sections.
Biological Information
ImmunogenGST-tagged recombinant human SPINK1.
Clone4D11.1
ConcentrationPlease refer to lot specific datasheet.
HostMouse
SpecificityExpected to react with both pro- and mature human SPINK1.
IsotypeIgG1κ
Species Reactivity
  • Human
Species Reactivity NoteHuman.
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • SPINK1
  • PCTT
  • PSTI
  • TCP
Purification MethodProtein G purified.
UniProt Number
Molecular Weight6.247/8.507 kDa (mature/pro-form) calculated. Uncharacterized band(s) may appear in some lysates.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting of SPINK1 GST fusion protein.

Western Blotting Analysis (WB): A 1:5000 dilution of this antibody detected 50 ng of recombinant human SPINK1 GST fusion protein.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
MABS1198 04054839034480