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ABT40 Anti-MFAP-5 (MAGP2) Antibody

This Anti-MFAP-5 (MAGP2) Antibody is validated for use in WB for the detection of MFAP-5 (MAGP2).

Anti-MFAP-5 (MAGP2) Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Cell Structure Research Sub-Category: Glycobiology, Adhesion (CAMs) Gene Symbol: MFAP5, MAGP2 UniProt Number: Q13361
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ABT40
100 µg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWBRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABT40
DescriptionAnti-MFAP-5 (MAGP2) Antibody
Alternate Names
  • Microfibrillar-associated protein 5
  • MFAP-5
  • MP25
  • Microfibril-associated glycoprotein 2
  • MAGP-2
Background InformationMicrofibril-associated protein 2 (MAGP-2), also known as microfibrillar associated protein 5 (MFAP-5), is a multifunctional secreted protein that acts as a promoter of tumor cell survival and angiogenesis. Through alphaVbeta3 integrin-mediated signaling, it is suggested that MAGP2 may provide a potential mechanistic link between MAGP2 and angiogenesis, as well as patient survival. Based on a high level of homology between MAGP (MFAP-2) and MAGP-2, both proteins are shown to bind to and activate Notch-1, as well as mediate the subsequent release of the Notch-1 extracellular domain.
References
Product Information
FormatAffinity Purified
Control
  • Human skeletal muscle tissue lysate.
PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationThis Anti-MFAP-5 (MAGP2) Antibody is validated for use in WB for the detection of MFAP-5 (MAGP2).
Key Applications
  • Western Blotting
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to human MFAP-5 (MAGP-2).
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
Species Reactivity
  • Human
Antibody TypePolyclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThis gene encodes a 25-kD microfibril-associated glycoprotein which is rich in serine and threonine residues. It lacks a hydrophobic carboxyl terminus and proline-, glutamine-, and tyrosine-rich regions, which are characteristics of a related 31-kDa microfibril-associated glycoprotein (MFAP2). The close similarity between these two proteins is confined to a central region of 60 aa where precise alignment of 7 cysteine residues occurs. The structural differences suggest that this encoded protein has some functions that are distinct from those of MFAP2.
Gene Symbol
  • MFAP5
  • MAGP2
Purification MethodAffinity Purfied
UniProt Number
UniProt SummaryFUNCTION: Component of the elastin-associated microfibrils.

SUBCELLULAR LOCATION: Secreted > extracellular space > extracellular matrix.
Molecular Weight~19 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blot in human skeletal muscle tissue lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected MFAP-5 (MAGP-2) in skeletal muscle tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
ABT40 04053252633300