Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

ABN335 Anti-LGI2 Antibody

Detect the LGI2 protein using this Anti-LGI2 validated for use in WB.

Anti-LGI2 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience Gene Symbol: Lgi2, LGI2 UniProt Number: Q8N0V4
View Products on Sigmaaldrich.com
ABN335
100 µg  
Purchase on Sigma-Aldrich

Special Offers

Overview

Replacement Information

Special Offers

100% Performance Guaranteed

Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWBRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABN335
DescriptionAnti-LGI2 Antibody
Alternate Names
  • Leucine-rich
  • glioma inactivated 2
  • LGIL2
Background InformationLeucine-rich repeat LGI family member 2 (LGI2) is a member of the LGI family. The LGI family consists of four highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 has been identified as a candidate tumor suppressor gene for glioma and plays a role in autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms. Despite its high homology with LGI1 and similar pattern of expression, mutations in LGI2 have not been found to be associated with ADTLE.
References
Product Information
FormatAffinity Purified
Control
  • HEK293 cell lysate
PresentationPurified rabbit polyclonal in buffer containing PBS with 0.02% sodium azide.
Quality LevelMQ100
Applications
ApplicationDetect the LGI2 protein using this Anti-LGI2 validated for use in WB.
Key Applications
  • Western Blotting
Application NotesImmunohistochemistry Analysis: A 1:500 dilution from a representative lot detected LGI2 in human midbrain tissue.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to the N-terminus of human LGI2.
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
SpecificityThis LGI2 antibody is predicted to be specific to LGI2 and not recognize other LGI proteins. Three isoforms of LGI2 are known to exist; this LGI2 antibody will recognize only the longest.
Species Reactivity
  • Human
Antibody TypePolyclonal Antibody
Gene Symbol
  • Lgi2
  • LGI2
Purification MethodAntigen Affinity Purified
UniProt Number
Molecular Weight~63 kDa observed. An uncharacterized band may appear at ~49 kDa in some lysates.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blot in HEK293 cell lysate.

Western Blot Analysis: 2 µg/mL of this antibody detected LGI2 in 15 µg/mL of HEK293 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
ABN335 04053252831157