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09-817 Anti-JMJD1C Antibody

Use Anti-JMJD1C Antibody (Rabbit Polyclonal Antibody) validated in WB, ICC to detect JMJD1C also known as jumonji domain containing 1C or TR-interacting protein 8.

Anti-JMJD1C Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Histone Modifying Proteins Gene Symbol: TRIP8, RP11-10C13.2, JMJD1C, JHDM2C UniProt Number: Q15652
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09-817
100 µg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, Rb, Chp, Rhesus MacaqueWB, ICCRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue Number09-817
DescriptionAnti-JMJD1C Antibody
Alternate Names
  • JMJD
  • jumonji domain containing 1C
  • TR-interacting protein 8
  • thyroid receptor interacting protein 8
  • probable JmjC domain-containing histone demethylation protein 2C
  • thyroid hormone receptor interactor 8
  • Thyroid receptor-interacting protein 8
  • Jumonji domain-containing protein 1C
Background InformationJMJD1C (jumonji domain-containing protein 1C) is also known as TRIP8 and mutations in this histone demethylase have been linked to certain forms of autism. JMJD1C is also thought to work in reactivating genes in embryonic stem cells, pancreatic islet and gastric cancer. JMJD1C has also been implicated as a gene expression regulator. JMJD1C with WHISTLE have recently been shown to also play a role in mouse testis development. JMJD1C has been identified as a nuclear-receptor coactivator and is a candidate gene for autism.
References
Product Information
FormatAffinity Purified
Control
  • HeLa nuclear extract
PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationUse Anti-JMJD1C Antibody (Rabbit Polyclonal Antibody) validated in WB, ICC to detect JMJD1C also known as jumonji domain containing 1C or TR-interacting protein 8.
Key Applications
  • Western Blotting
  • Immunocytochemistry
Application NotesImmunocytochemistry Analysis: 1:500 dilution from a representative lot detected JMJD1C in HeLa cells.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to human JMJD1C.
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
Species Reactivity
  • Human
  • Rabbit
  • Chimpanzee
  • Rhesus Macaque
Species Reactivity NoteDemonstrated to react with Human. Predicted to react with Rabbit, Chimpanzee, Rhesus Macaque, and Orangutan based on 100% sequence homology.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • TRIP8
  • RP11-10C13.2
  • JMJD1C
  • JHDM2C
Purification MethodAffinity Purfied
UniProt Number
UniProt SummaryFUNCTION: Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity).

COFACTOR: Binds 1 Fe2+ ion per subunit (By similarity).

SUBUNIT STRUCTURE: Interacts specifically with the ligand-binding domain of the thyroid receptor (TR). Requires the presence of thyroid hormone for its interaction.

SUBCELLULAR LOCATION: Nucleus (By similarity).

DOMAIN: Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors (By similarity).

PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.

SEQUENCE SIMILARITIES: Belongs to the JHDM2 histone demethylase family.

Contains 1 JmjC domain.

SEQUENCE CAUTION: The sequence AAC41741.1 differs from that shown. Reason: Frameshift at position 2171.

The sequence CAD97921.1 differs from that shown. Reason: Frameshift at position 1697.

The sequence CAI10947.1 differs from that shown. Reason: Erroneous gene model prediction.
Molecular Weight~284 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blot in HeLa nuclear extract.

Western Blot Analysis: 1 µg/mL of this antibody detected JMJD1C on 10 µg of HeLa nuclear extract.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
09-817 04053252415296