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MAB1962Z Anti-Integrin β2 Antibody, clone P4H9, azide free

Anti-Integrin β2 Antibody, clone P4H9, azide free detects level of Integrin β2 & has been published & validated for use in IH.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Cell Structure Research Sub-Category: Integrins Gene Symbol: ITGB2, LFA-1, MAC-1, MF17, LCAMB, MFI7, LAD, CD18 UniProt Number: P05107
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MAB1962Z
100 µg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HIHC, FUNCMPurifiedMonoclonal Antibody
Description
Catalogue NumberMAB1962Z
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-Integrin β2 Antibody, clone P4H9, azide free
Alternate Names
  • CD18
  • MAB1962
Product Information
FormatPurified
PresentationSterile-filtered liquid containing no preservatives.
Quality LevelMQ100
Applications
ApplicationAnti-Integrin β2 Antibody, clone P4H9, azide free detects level of Integrin β2 & has been published & validated for use in IH.
Key Applications
  • Immunohistochemistry
  • Affects Function
Application NotesSuitable for use in immunofluorescence.

Also suitable for aggregation inhibition assays using hematopoeitic cells or EBV-transformed B lymphocytes.

For extensive dilution, protein-containing or other stabilizing medium should be used. Final working dilutions must be determined by end user.
Biological Information
CloneP4H9
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostMouse
Specificitybeta2 integrin on hematopoeitic cells. Not present on platelets, endothelial cells, epithelial cells or fibroblasts.
IsotypeIgG3
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThe ITGB2 protein product is the integrin beta chain beta 2. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.
Gene Symbol
  • ITGB2
  • LFA-1
  • MAC-1
  • MF17
  • LCAMB
  • MFI7
  • LAD
  • CD18
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P05107 # Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha- D/beta-2 is a receptor for ICAM3 and VCAM1.
SIZE: 769 amino acids; 84782 Da
SUBUNIT: Heterodimer of an alpha and a beta subunit. Beta-2 associates with either alpha-L, alpha-M, alpha-X or alpha-D. Interacts with COPS5 and RANBP9.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
PTM: Both Ser-745 and Ser-756 become phosphorylated when T-cells are exposed to phorbol esters. Phosphorylation on Thr-758 (but not on Ser-756) allows interaction with 14-3-3 proteins.DISEASE:SwissProt: P05107 # Defects in ITGB2 are the cause of leukocyte adhesion deficiency type I (LAD1) [MIM:116920]. LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions.
SIMILARITY: SwissProt: P05107 ## Belongs to the integrin beta chain family. & Contains 1 VWFA domain.
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain at 2-8°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size100 µg
Global Trade Item Number
Catalogue Number GTIN
MAB1962Z 04053252610967