Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

MABS807 Anti-IKBKB, clone 10A2 Antibody

Anti-IKBKB, clone 10A2 Antibody is an antibody against IKBKB for use in Western Blotting.

Anti-IKBKB, clone 10A2 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Developmental Signaling Gene Symbol: IKBKB, IKKB UniProt Number: O14920
MABS807
100 µL  
Purchase on Sigma-Aldrich

Special Offers

Overview

Replacement Information

Special Offers

100% Performance Guaranteed

Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWBMAscitesMonoclonal Antibody
Description
Catalogue NumberMABS807
Replaces04-366
DescriptionAnti-IKBKB, clone 10A2 Antibody
Alternate Names
  • Inhibitor of nuclear factor kappa-B kinase subunit beta
  • I-kappa-B-kinase beta
  • IKK-B
  • IKK-beta
  • IkBKB
  • IKBKB
Background InformationInhibitor of kappa light polypeptide gene enhancer in B-cells (IKBKB), also known as kinase beta or IKK2/IKKB, is a member of the IKK complex which is composed of IKK-alpha, IKK-beta, IKK-gamma and IKAP. Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination. IKK-beta has been shown to activate NF-kB and phosphorylate IKB-alpha and beta. Phosphorylation of 2 sites at the activation loop of IKK-beta is essential for activation of IKK by TNF and IL1. Once activated, IKK-beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response. Additionally, IKK-beta activity can also be regulated by MEKK-1.
References
Product Information
FormatAscites
PresentationMouse monoclonal IgG1ascitic fluid containing 0.03% sodium azide.
Quality LevelMQ300
Applications
ApplicationAnti-IKBKB, clone 10A2 Antibody is an antibody against IKBKB for use in Western Blotting.
Key Applications
  • Western Blotting
Biological Information
ImmunogenPurified recombinant fragment of IKBKB expressed in E. Coli.
Clone10A2
ConcentrationPlease refer to lot specific datasheet.
HostMouse
IsotypeIgG1
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Gene Symbol
  • IKBKB
  • IKKB
Purification MethodUnpurified
UniProt Number
Molecular Weight~87 and ~26 kDa observed. Uncharacterized bands may be observed in some lysate(s).
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in truncated IKBKB recombinant protein and K562 cell lysate.

Western Blotting Analysis (WB): A 1:500-2,000 dilution of this antibody detected IKBKB in truncated IKBKB recombinant protein and K562 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
MABS807 04055977172188