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ABE1306 Anti-DOM3Z Antibody

Anti-DOM3Z is an antibody against DOM3Z for use in Western Blotting.

Anti-DOM3Z Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Nuclear Receptors Gene Symbol: DXO, DOM3L, DOM3Z, NG6 UniProt Number: O77932
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ABE1306
100 µg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, M, RWBRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABE1306
DescriptionAnti-DOM3Z Antibody
Alternate Names
  • Decapping and exoribonuclease protein
  • DXO
  • Dom-3 homolog Z
  • DOM3Z
Background InformationDecapping and exoribonuclease protein (DOM3Z), also known as DXO, Dom-3 homolog Z, and encoded by the gene symbol DOM3Z/ DOM3L/ NG6, is a ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap. DOM3Z is part of a pre-mRNA capping quality control and has decapping, pyrophosphohydrolase and 5'-3' exonuclease activities. DOM3Z has a decapping activity toward incomplete 5' end cap mRNAs (such as unmethylated 5' end-capped RNA), which in return releases GpppN and 5' end monophosphate RNA. The 5' end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Additionally, DOM3Z has been implied to have RNA 5'-pyrophosphohydrolase activity and to release pyrophosphates by hydrolyzing the 5' end triphosphate. DOM3Z is located in the nucleus, and expressed ubiquitously.
References
Product Information
FormatAffinity Purified
PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-DOM3Z is an antibody against DOM3Z for use in Western Blotting.
Key Applications
  • Western Blotting
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to human DOM3Z.
EpitopeUnknown
ConcentrationPlease refer to lot specific datasheet.
HostRabbit
Species Reactivity
  • Human
  • Mouse
  • Rat
Species Reactivity NoteHuman, Mouse, Rat. Predicted to react with Bovine based on 100% sequence homology.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • DXO
  • DOM3L
  • DOM3Z
  • NG6
Purification MethodAffinity Purfied
UniProt Number
Molecular Weight~45 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in human pancreas tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected DOM3Z in 10 µg of human pancreas tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
ABE1306 04055977113594