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IM55 Anti-Cathepsin K Mouse mAb (182-12G5)

Anti-Cathepsin K Mouse mAb (182-12G5) MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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Overview

Replacement Information

Key Spec Table

Species ReactivityHostAntibody Type
HMMonoclonal Antibody
Description
Overview

This product has been discontinued.



Recognizes the ~28 kDa cathepsin K protein in human osteoclasts.
Catalogue NumberIM55
Brand Family Calbiochem®
References
ReferencesInaoka, T., et al. 1995. Biochem. Biophys. Res. Commun. 206, 89.
Tezuka, K., et al. 1994. J. Biol. Chem. 269, 1106.
Barrett, A.J. and Kirschke, H. 1981. Meth. Enzymol. 80, 535.
Product Information
DeclarationManufactured by Daiichi Fine Chemical Co., Ltd. Not available for sale in Japan.
FormLiuid
FormulationIn 100 mM sodium phosphate buffer, 0.1% BSA, pH 7.0
Positive controlOsteoclasts
Preservative≤0.1% sodium azide
Quality LevelMQ100
Applications
Key Applications Immunoblotting (Western Blotting)
Application NotesImmunoblotting (5 µg/ml)
Application CommentsAntibody should be titrated for optimal results in individual systems.
Biological Information
Immunogena synthetic peptide (SEDAYPYVGQEESC) corresponding to amino acids 182-195 of human cathepsin K
ImmunogenHuman
Clone182-12G5
HostMouse
IsotypeIgG₁
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage -20°C
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
IM55 0

Documentation

Anti-Cathepsin K Mouse mAb (182-12G5) SDS

Title

Safety Data Sheet (SDS) 

Anti-Cathepsin K Mouse mAb (182-12G5) Certificates of Analysis

TitleLot Number
IM55

References

Reference overview
Inaoka, T., et al. 1995. Biochem. Biophys. Res. Commun. 206, 89.
Tezuka, K., et al. 1994. J. Biol. Chem. 269, 1106.
Barrett, A.J. and Kirschke, H. 1981. Meth. Enzymol. 80, 535.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-May-2009 JSW
ApplicationImmunoblotting (5 µg/ml)
DescriptionPurified mouse monoclonal antibody (see application references). Recognizes the ~28 kDa cathepsin K protein.
BackgroundCathepsins are normal lysosomal proteases, which are expressed in all cells where they function in protein turnover. They have also been shown to be capable of degrading extracellular matrix proteins. Cathepsin K, also known as OC-2, is a cysteine endoproteinase that is predominantly expressed in osteoclasts and is structurally and functionally related to cathepsin L and cathepsin S. The cloned human cDNA encodes a protein of 329 amino acids showing a 94% homology to rabbit cathepsin K. Northern blot analysis show elevated levels of cathepsin K mRNA in osteoarthritic hip bones and very high levels in osteoclastoma compared to low levels in other tissues such as kidney, liver, spleen and lung. The predominant expression of cathepsin K in osteoclasts suggests an important role in human osteoclastic bone resorption and may provide possible rationale for the treatment of osteoporosis and certain forms of arthritis.
HostMouse
Immunogen speciesHuman
Immunogena synthetic peptide (SEDAYPYVGQEESC) corresponding to amino acids 182-195 of human cathepsin K
Clone182-12G5
IsotypeIgG₁
Specieshuman
Positive controlOsteoclasts
FormLiuid
FormulationIn 100 mM sodium phosphate buffer, 0.1% BSA, pH 7.0
Preservative≤0.1% sodium azide
CommentsAntibody should be titrated for optimal results in individual systems.
Storage Avoid freeze/thaw
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Toxicity Standard Handling
ReferencesInaoka, T., et al. 1995. Biochem. Biophys. Res. Commun. 206, 89.
Tezuka, K., et al. 1994. J. Biol. Chem. 269, 1106.
Barrett, A.J. and Kirschke, H. 1981. Meth. Enzymol. 80, 535.