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MABC1832-25UG Anti-CD44v4 Antibody, clone C44Mab-108

This mouse monoclonal Anti-CD44v4, clone C44Mab-108, Cat. No. MABC1832 is tested for use in Flow Cytometry, Immunohistochemistry, Western Blotting, and ELISA, for the detection of CD44v4.

NewMABC1832-25UG
25 μg  
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Overview

Replacement Information
Description
Catalogue NumberMABC1832-25UG
DescriptionAnti-CD44v4 Antibody, clone C44Mab-108
Alternate Names
  • CDw44
  • Epican
  • Extracellular matrix receptor III (ECMR-III) GP90 lymphocyte homing/adhesion receptor
  • HUTCH-I
  • Heparan sulfate proteoglycan
  • Hermes antigen
  • Hyaluronate receptor
  • Phagocytic glycoprotein 1 (PGP-1)
  • Phagocytic glycoprotein I (PGP-I)
  • LHR
  • MDU2
  • MDU3
  • MIC4
Background InformationCD44 antigen (UniProt: P16070; also known as CDw44, Epican, Extracellular matrix receptor III (ECMR-III), GP90 lymphocyte homing/adhesion receptor, HUTCH-I, Heparan sulfate proteoglycan, Hermes antigen, Hyaluronate receptor, Phagocytic glycoprotein 1 (PGP-1), Phagocytic glycoprotein I (PGP-I)) is encoded by the CD44 (also known as LHR, MDU2, MDU3, MIC4) gene (Gene ID: 960) in human. CD44 is a Type 1 transmembrane glycoprotein involved in cell adhesion, migration, and proliferation. It also plays a role in lymphocyte activation, tumor metastasis, and wound healing. It is encoded by the CD44 gene, and it is expressed in a wide range of cell types. The protein's structure includes a hyaluronic acid (HA) binding domain, a stem region, and a variable extracellular domain. Alternative splicing may produce 19 isoforms. CD44 splice variants (CD44v) play a role in tumorigenesis and malignancy. It is also implicated in various other diseases, including autoimmune disorders, cardiovascular diseases and fibrosis.
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ200
Applications
ApplicationThis mouse monoclonal Anti-CD44v4, clone C44Mab-108, Cat. No. MABC1832 is tested for use in Flow Cytometry, Immunohistochemistry, Western Blotting, and ELISA, for the detection of CD44v4.
Key Applications
  • Flow Cytometry
  • ELISA
  • Western Blotting
  • Immunohistochemistry
Application NotesTested Applications

ELISA Analysis: A representative lot detected CD44v4 in ELISA applications (Suzuki, H., et al. (2023). Curr. Issues Mol. Biol. 45(3):1875-1888).

Western Blotting Analysis: A representative lot detected CD44v4 in Western Blotting applications (Suzuki, H., et al. (2023). Curr. Issues Mol. Biol. 45(3):1875-1888).

Flow Cytometry Analysis: A representative lot detected CD44v4 in Flow Cytometry applications (Suzuki, H., et al. (2023). Curr Issues Mol Biol. 45(3):1875-1888).

Immunohistochemistry Applications: A representative lot detected CD44v4 in Immunohistochemistry applications (Suzuki, H., et al. (2023). Curr. Issues Mol. Biol. 45(3):1875-1888).

Note: Actual optimal working dilutions must be determined by end user as specimens, and experimental conditions may vary with the end user.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to 19 amino acids from the N-terminal extracellular domain of human CD44v4.
EpitopeN-terminal extracellular domain
CloneC44Mab-108
Concentration0.5 mg/mL. Please refer to guidance on suggested starting dilutions and/or titers per application and sample type.
HostMouse
SpecificityClone C44Mab-108 is a mouse monoclonal antibody that detects CD44v4. It targets an epitope within 19 amino acids from the N-terminal extracellular domain of the protein.
IsotypeIgG1κ
Species Reactivity
  • Human
Species Reactivity NoteHuman. Predicted to react with Monkey based on 100% sequence homology.
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • CD44
Purification MethodProtein G purified
UniProt Number
Molecular WeightTarget molecular weight 81.54 kDa calculated.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Flow Cytometry in a CHO cells overexpressing CD44v3-10.

Flow Cytometry Analysis: 1.0 µg of this antibody detected CD44v6 in a one million CHO cells overexpressing CD44v3-10.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsRecommended storage: +2°C to +8°C.
Packaging Information
Material Size25 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
MABC1832-25UG 04065271270114