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MABF238-I-25UG Anti-CD38 Antibody, clone 2H3-2

This mouse monoclonal Anti-CD38, clone 2H3-2, Cat. No. MABF238-I is tested for use in Flow Cytometry, for the detection of ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1.

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MABF238-I-25UG
25 μg  
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Overview

Replacement Information
Description
Catalogue NumberMABF238-I-25UG
DescriptionAnti-CD38 Antibody, clone 2H3-2
Alternate Names
  • ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
  • EC:3.2.2.6
  • 2'-phospho-ADP-ribosyl cyclase
  • 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase
  • 2'-phospho-cyclic-ADP-ribose transferase
  • ADP-ribosyl cyclase 1
  • ADPRC 1
  • Cyclic ADP-ribose hydrolase 1
  • cADPr hydrolase 1
  • T10
Background InformationADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (UniProt: P28907; also known as EC:3.2.2.6, 2'-phospho-ADP-ribosyl cyclase, 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase, 2'-phospho-cyclic-ADP-ribose transferase, ADP-ribosyl cyclase 1, ADPRC 1, Cyclic ADP-ribose hydrolase 1, cADPr hydrolase 1, T10, CD38) is encoded by the CD38 gene (Gene ID: 952) in human. CD38, a member of the ADP-ribosyl cyclase family, is a single-pass type II membrane glycoprotein that contains a short cytoplasmic domain (aa 1-21), a transmembrane domain (aa 22-42), and a long extracellular domain (aa 43-300). It is expressed in high levels in pancreas, liver, kidney, brain, and in malignant lymphoma and neuroblastoma. It plays a role in cell adhesion, migration, and signal transduction. It is preferentially expressed at both early and late stages of the B and T-cell maturation and is detected on erythroid and myeloid progenitors in bone marrow, where the level of surface expression was shown to decrease during differentiation of blast-forming unit E to colony-forming unit E. CD38 is a bifunctional enzyme with both ADP-ribosyl cyclase and cADPR hydrolase activities. Its catalytic activity resides in the extracellular domain that can both generate and degrade cyclic-ADP ribose and can catalyze the base-exchange reaction between NADP+ and nicotinic acid to produce Nicotinic acid adenine dinucleotide phosphate (NAADP+). CD38 also moonlights as a receptor in cells of the immune system where it serves as a lymphocyte receptor and is a considered to be a prognostic marker for survival with B-cell chronic lymphoblastic leukemia.
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal antibody IgM in PBS with 0.05% sodium azide.
Quality LevelMQ200
Applications
ApplicationThis mouse monoclonal Anti-CD38, clone 2H3-2, Cat. No. MABF238-I is tested for use in Flow Cytometry, for the detection of ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1.
Key Applications
  • Flow Cytometry
Biological Information
ImmunogenRecombinant fragment corresponding to the extracellular domain of Human CD38.
EpitopeExtracellular domain
Clone2H3-2
Concentration1.0 mg/mL. Please refer to guidance on suggested starting dilutions and/or titers per application and sample type.
HostMouse
SpecificityClone 2H3-2 is a mouse monoclonal antibody that detects CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1).
IsotypeIgMκ
Species Reactivity
  • Human
Species Reactivity NoteHuman.
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • CD38
Purification MethodLigatrap
UniProt Number
Molecular Weight34.33 kDa calculated.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Flow Cytometry in Raji cells.

Flow Cytometry Analysis: 1 µg of this antibody detected CD38 in one million Raji cells.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsRecommend storage at +2°C to +8°C. For long term storage antibodies can be kept at -20°C. Avoid repeated freeze-thaws.
Packaging Information
Material Size25 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
MABF238-I-25UG 04065267613352