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07-208-25UG Anti-AIF (rabbit polyclonal IgG)

Anti-AIF (Apoptosis Inducing Factor) Antibody detects level of AIF (Apoptosis Inducing Factor) & has been published & validated for use in WB.

Anti-AIF (rabbit polyclonal IgG) MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: AIFM1, MGC111425, PDCD8, AIF UniProt Number: O95831
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07-208-25UG
25 μg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, M, RWBRbPurifiedPolyclonal Antibody
Description
Catalogue Number07-208-25UG
Brand Family Upstate
Trade Name
  • Upstate
DescriptionAnti-AIF (rabbit polyclonal IgG)
Product Information
FormatPurified
Presentation0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Quality LevelMQ100
Applications
ApplicationAnti-AIF (Apoptosis Inducing Factor) Antibody detects level of AIF (Apoptosis Inducing Factor) & has been published & validated for use in WB.
Key Applications
  • Western Blotting
Biological Information
Immunogenpeptide corresponding to amino acids 593-606 of human Apoptosis Inducing Factor, AIF (C-KDGEQHEDLNEVAK), containing a N-terminal cysteine
ConcentrationPlease refer to lot specific datasheet.
HostRabbit
SpecificityAIF
IsotypeIgG
Species Reactivity
  • Human
  • Mouse
  • Rat
Antibody TypePolyclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThis gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells that is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it effects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Three alternative transcripts encoding different isoforms have been identified for this gene.
Gene Symbol
  • AIFM1
  • MGC111425
  • PDCD8
  • AIF
Purification MethodProtein A chromatography
UniProt Number
UniProt SummaryFUNCTION: SwissProt: O95831 # Probable oxidoreductase that acts as a caspase- independent mitochondrial effector of apoptotic cell death. Extramitochondrial AIF induces nuclear chromatin condensation and large scale DNA fragmentation (in vitro).
COFACTOR: FAD.
SIZE: 613 amino acids; 66901 Da
SUBUNIT: Binds to DNA in a sequence-independent manner.
SUBCELLULAR LOCATION: Mitochondrion intermembrane space. Nucleus. Note=Translocated to the nucleus upon induction of apoptosis.
SIMILARITY: SwissProt: O95831 ## Belongs to the FAD-dependent oxidoreductase family.
Molecular Weight57kDa
Product Usage Statements
Quality Assuranceroutinely evaluated by immunoblot on a mouse liver preparation
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions2 years at -20°C
Packaging Information
Material Size25 μg
Global Trade Item Number
Catalogue Number GTIN
07-208-25UG 04054839337734