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05-23-0101
Sigma-AldrichAngiotensin II, Human - CAS 4474-91-3 - Calbiochem
Plays an important role in the regulation of blood pressure.
More>>Plays an important role in the regulation of blood pressure. Less<<
MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Plays an important role in the regulation of blood pressure. Stimulates the release of aldosterone from the adrenal gland. Inhibits adenylate cyclase activity in spontaneously hypertensive rats. Has strong vasoconstrictive effects. Increases the entry of Ca2+ in heart muscle via voltage-sensitive channels and activates myosin light chain kinase. Also elicits an increase in voltage-dependent delayed rectifier K+ current in neurons. Activates JAK2 in smooth muscle cells. Activates p125FAK and a cytosolic 115-120 kDa calcium-dependent tyrosine kinase in rat epithelial cells. Also activates p60c-srcas well as ERK1/2, JNK, and p38 MAP Kinase in vascular smooth muscle cells.
Catalogue Number
05-23-0101
Brand Family
Calbiochem®
Synonyms
DRVYIHPF
References
References
Zhu, M., et al. 2000. J. Neurophysiol.84, 2494. Natarajan, R., et al. 1999. Hypertension 33, 378. Mazzolai, L., et al. 1998. Hypertension 31, 1324. Earp, H.S., et al. 1995. J. Biol. Chem. 270, 28440. Ishida, M., et al. 1995. Circ. Res. 77, 1053. Vyas, S.J., and Jackson, E.K. 1995. J. Pharmacol. Exp. Ther. 273, 768.
Angiotensin II, Human - CAS 4474-91-3 - Calbiochem Certificates of Analysis
Title
Lot Number
05-23-0101
References
Reference overview
Zhu, M., et al. 2000. J. Neurophysiol.84, 2494. Natarajan, R., et al. 1999. Hypertension 33, 378. Mazzolai, L., et al. 1998. Hypertension 31, 1324. Earp, H.S., et al. 1995. J. Biol. Chem. 270, 28440. Ishida, M., et al. 1995. Circ. Res. 77, 1053. Vyas, S.J., and Jackson, E.K. 1995. J. Pharmacol. Exp. Ther. 273, 768.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
12-May-2008 JSW
Synonyms
DRVYIHPF
Description
Functions in blood pressure maintenance. Stimulates the release of aldosterone from the adrenal gland. Has strong vasoconstrictive effects. Increases the entry of Ca2+ in heart muscle via voltage-sensitive channels and activates myosin light chain kinase. Activates JAK2 in smooth muscle cells. Activates p125FAK and a cytosolic 115-120 kDa calcium-dependent tyrosine kinase in rat epithelial cells. Also activates pp60c-src in vascular smooth muscle cells. Inhibits adenylate cyclase activity in spontaneously hypertensive rats.
Form
White to off-white solid
CAS number
4474-91-3
RTECS
BW2165000
Chemical formula
C₅₀H₇₁N₁₃O₁₂
Peptide Sequence
H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH
Purity
≥98% by HPLC
Solubility
5% acetic acid (1 mg/ml) or H₂O (1 mg/ml)
Storage
-20°C Hygroscopic
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.
Toxicity
Standard Handling
Merck USA index
14 651
References
Zhu, M., et al. 2000. J. Neurophysiol.84, 2494. Natarajan, R., et al. 1999. Hypertension 33, 378. Mazzolai, L., et al. 1998. Hypertension 31, 1324. Earp, H.S., et al. 1995. J. Biol. Chem. 270, 28440. Ishida, M., et al. 1995. Circ. Res. 77, 1053. Vyas, S.J., and Jackson, E.K. 1995. J. Pharmacol. Exp. Ther. 273, 768.
