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505855 Adenovirus Proteinase Inhibitor, NSC 37249 - CAS 2907-88-2 - Calbiochem

An inhibitor of adenovirus cysteine proteinase AVP that simultaneously targets AVP co-factor pVIc N-terminal binding pocket (Ki = 150 nM) and AVP-pVIc substrate-binding site (Ki = 400 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-(Dicyclohexylamino)-N-(4-(4-((2-(dicyclohexylamino)acetyl)amino)phenyl)sulfonylphenyl)acetamide, N,Nʹ-(Sulfonyldi-4,1-phenylene)bis(2-(dicyclohexylamino)acetamide, AVP Inhibitor

Primary Target: AVP co-factor pVIc (GVQSLKRRRCF) N-terminal binding pocket
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Overview

Key Spec Table

CAS #Empirical Formula
2907-88-2C₄₀H₅₈N₄O₄S

Products

Catalogue NumberPackaging Qty/Pack
5.05855.0001 Glass bottle 10 mg
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Description
OverviewA sulfonyldiphenylene-bis-dicyclohexylaminoacetamide compound that acts as a potent and selective inhibitor against adenovirus cysteine proteinase AVP by targeting simultaneously AVP co-factor pVIc (GVQSLKRRRCF) N-terminal binding pocket (Ki = 150 nM) and AVP-pVIc substrate-binding site (Ki = 400 nM), blocking both AVP-pVIc active complex formation (IC50 = 140 nM; [substrate] = 5 µM & [pVIc] = 40 µM) and catalytic activity (IC50 = 490 nM; [substrate] = 5 µM) without affecting trypsin or papain protease activity even at concentrations as high as 10 µM.
Catalogue Number505855
Brand Family Calbiochem®
Synonyms2-(Dicyclohexylamino)-N-(4-(4-((2-(dicyclohexylamino)acetyl)amino)phenyl)sulfonylphenyl)acetamide, N,Nʹ-(Sulfonyldi-4,1-phenylene)bis(2-(dicyclohexylamino)acetamide, AVP Inhibitor
References
ReferencesMcGrath, W.J., et al. 2013. FEBS Lett. 587, 2332.
Product Information
CAS number2907-88-2
FormOff-white powder
Hill FormulaC₄₀H₅₈N₄O₄S
Chemical formulaC₄₀H₅₈N₄O₄S
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary Target AVP co-factor pVIc (GVQSLKRRRCF) N-terminal binding pocket
Secondary targetAVP-pVIc substrate-binding site
Purity≥90% by HPLC
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
5.05855.0001 04055977263091