118501 Sigma-AldrichATM/ATR Kinase Inhibitor - CAS 905973-89-9 - Calbiochem
The ATM/ATR Kinase Inhibitor, also referenced under CAS 905973-89-9, controls the biological activity of ATM/ATR Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
More>> The ATM/ATR Kinase Inhibitor, also referenced under CAS 905973-89-9, controls the biological activity of ATM/ATR Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: CGK 733
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Overview
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Key Spec Table
| CAS # | Empirical Formula |
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| 905973-89-9 | C₂₃H₁₈Cl₃FN₄O₃S |
Products
| Catalogue Number | Packaging | Qty/Pack | |
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| 118501-5MG | Plastic ampoule | 5 mg |
| Description | |
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| Overview | A cell-permeable thiourea compound that selectively inhibits the kinase activity of ATM and ATR (IC50 = ~200 nM) without significant effect against other PIKK family members (PI 3-K, mTOR, and DNA-PK) or kinases that are known to phosphorylate p53 (ERK, CK1, Cdk2, JNK, PKC, CAK, Chk1, PKR, and p38). Shown to reverse senescence in human primary BJ and HMEC cells. Unlike LY 294002 (Cat. No. 440202 and 440204), this inhibitor does not interfere with cellular PI 3-K/PDK1/Akt signaling pathway. |
| Catalogue Number | 118501 |
| Brand Family | Calbiochem® |
| Synonyms | CGK 733 |
| Product Information | |
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| CAS number | 905973-89-9 |
| ATP Competitive | N |
| Form | Pale yellow solid |
| Hill Formula | C₂₃H₁₈Cl₃FN₄O₃S |
| Chemical formula | C₂₃H₁₈Cl₃FN₄O₃S |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | ATM/ATR |
| Primary Target IC<sub>50</sub> | ~200 nM against ATM and ATR |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
| Dimensions |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 118501-5MG | 04055977224054 |
Documentation
ATM/ATR Kinase Inhibitor - CAS 905973-89-9 - Calbiochem SDS
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ATM/ATR Kinase Inhibitor - CAS 905973-89-9 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 118501 |
References
| Reference overview |
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| Goldstein, M., et al. 2008. Toxicol. Appl. Pharmacol. in press. Crescenzi, E., et al. 2008. Clin. Cancer Res. 14, 1877. Cruet-Hennequart, S., et al. 2008. DNA Repair 7, 582. Won, J., et al. 2006. Nat. Chem. Biol. 2, 369. (RETRACTED) |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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