118490 Sigma-AldrichATIC Dimerization Inhibitor - CAS 1402453-15-9 - Calbiochem
Synonyms: Ac-Arg-Ph(4-NO2)-NEt2, ATIC Inhibitor, AICAR Tfase Inhibitor, AICAR transformylase Inhibitor, AICAR Tranformylase/Inosine Monophosphate Cyclohydrolase Dimerization Inhibitor, AMPK Signaling Activator XI
Recommended Products
Overview
Products
Catalogue Number | Packaging | Qty/Pack | |
---|---|---|---|
118490-10MG | Glass bottle | 10 mg |
Description | |
---|---|
Overview | A cell-permeable dipeptide that reversibly blocks the homodimerization of aminoimidazole carboxamide ribonucleotide transformylase/inosine nomophosphate cyclohydrolase (ATIC) and inhibits its activity (Ki = 691 nM, Kd = 240 nM). AITC is a bifunctional enzyme that catalyzes the last two steps of de novo purine biosynthesis. Increases the intracellular levels of AICAR leading to the activation of AMP-activated protein kinase (AMPK). Shown to reduce cell viability in a dose-dependent manner. Exhibits a longer half-life and sustained AMPK activation (~ 24 hours) compared to AICA-riboside (Cat. No. 123040). |
Catalogue Number | 118490 |
Brand Family | Calbiochem® |
Synonyms | Ac-Arg-Ph(4-NO2)-NEt2, ATIC Inhibitor, AICAR Tfase Inhibitor, AICAR transformylase Inhibitor, AICAR Tranformylase/Inosine Monophosphate Cyclohydrolase Dimerization Inhibitor, AMPK Signaling Activator XI |
References | |
---|---|
References | Spurr, I.B., et al. 2012. ChemBioChem 13, 1628. |
Product Information | |
---|---|
CAS number | 1402453-15-9 |
Form | White solid |
Hill Formula | C₂₁H₃₃N₇O₅ |
Chemical formula | C₂₁H₃₃N₇O₅ |
Reversible | Y |
Structure formula Image | |
Quality Level | MQ100 |
Biological Information | |
---|---|
Primary Target | ATIC |
Primary Target K<sub>i</sub> | 691 nM (Kd |
Purity | ≥97% by HPLC |
Physicochemical Information | |
---|---|
Cell permeable | Y |
Peptide Sequence | Ac-Arg-Ph(4-NO2)-NEt2 |
Packaging Information | |
---|---|
Packaged under inert gas | Packaged under inert gas |
Global Trade Item Number | |
---|---|
Catalogue Number | GTIN |
118490-10MG | 04055977224023 |