Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

118490 ATIC Dimerization Inhibitor - CAS 1402453-15-9 - Calbiochem

Overview

Products

Catalogue NumberPackaging Qty/Pack
118490-10MG Glass bottle 10 mg
Description
OverviewA cell-permeable dipeptide that reversibly blocks the homodimerization of aminoimidazole carboxamide ribonucleotide transformylase/inosine nomophosphate cyclohydrolase (ATIC) and inhibits its activity (Ki = 691 nM, Kd = 240 nM). AITC is a bifunctional enzyme that catalyzes the last two steps of de novo purine biosynthesis. Increases the intracellular levels of AICAR leading to the activation of AMP-activated protein kinase (AMPK). Shown to reduce cell viability in a dose-dependent manner. Exhibits a longer half-life and sustained AMPK activation (~ 24 hours) compared to AICA-riboside (Cat. No. 123040).
Catalogue Number118490
Brand Family Calbiochem®
SynonymsAc-Arg-Ph(4-NO2)-NEt2, ATIC Inhibitor, AICAR Tfase Inhibitor, AICAR transformylase Inhibitor, AICAR Tranformylase/Inosine Monophosphate Cyclohydrolase Dimerization Inhibitor, AMPK Signaling Activator XI
References
ReferencesSpurr, I.B., et al. 2012. ChemBioChem 13, 1628.
Product Information
CAS number1402453-15-9
FormWhite solid
Hill FormulaC₂₁H₃₃N₇O₅
Chemical formulaC₂₁H₃₃N₇O₅
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetATIC
Primary Target K<sub>i</sub>691 nM (Kd
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceAc-Arg-Ph(4-NO2)-NEt2
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
118490-10MG 04055977224023