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171262 AMPK Activator V, Ampkinone - CAS 1233082-79-5 - Calbiochem

The AMPK Activator V, Ampkinone modulates the biological activity of AMPK. This small molecule/inhibitor is primarily used for Biochemicals applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: AKN, AMPK Signaling Activator V

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171262
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1233082-79-5C₃₁H₂₃NO₆

Products

Catalogue NumberPackaging Qty/Pack
171262-5MG Glass bottle 5 mg
Description
OverviewA cell-permeable benzopyran compound that stimulates both LKB1 and CaMKK-mediated AMPK activity indirectly with no noticeable effect on purified AMPK, cellular AMP/ATP ratio, PI 3-K/Akt signaling and respiratory chain, and displays antidiabetic and antiobesity properties. Shown to induce phosphorylation of AMPK-Thr172 and ACC-Ser79 in L6 cells (EC50 = 4.3 µM), C2C12 myocytes, 3T3-L1 preadipocytes and HepG2 hepatic cells, and enhance glucose uptake and insulin sensitivity in high fat-diet-induced obesity mouse model (10 mg/kg, s.c.) with the lowering of cholesterol and nonesterified fatty acids.
Catalogue Number171262
Brand Family Calbiochem®
SynonymsAKN, AMPK Signaling Activator V
References
ReferencesOh, S., et al. 2010. J. Med. Chem. 53, 7405.
Product Information
CAS number1233082-79-5
FormYellow powder
Hill FormulaC₃₁H₂₃NO₆
Chemical formulaC₃₁H₂₃NO₆
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Regulatory Review
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
171262-5MG 04055977207187

Documentation

AMPK Activator V, Ampkinone - CAS 1233082-79-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

AMPK Activator V, Ampkinone - CAS 1233082-79-5 - Calbiochem Certificates of Analysis

TitleLot Number
171262

References

Reference overview
Oh, S., et al. 2010. J. Med. Chem. 53, 7405.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-September-2012 JSW
SynonymsAKN, AMPK Signaling Activator V
DescriptionA cell-permeable benzopyran compound that stimulates both LKB1 and CaMKK-mediated AMPK activity indirectly with no noticeable effect on purified AMPK, cellular AMP/ATP ratio, PI 3-K/Akt signaling and respiratory chain, and displays antidiabetic and antiobesity properties. Shown to induce phosphorylation of AMPK-Thr172 and ACC-Ser79 in L6 cells (EC50 = 4.3 µM), C2C12 myocytes, 3T3-L1 preadipocytes and HepG2 hepatic cells, and enhance glucose uptake and insulin sensitivity in high fat-diet-induced obesity mouse model (10 mg/kg, s.c.) with the lowering of cholesterol and nonesterified fatty acids.
FormYellow powder
Intert gas (Yes/No) Packaged under inert gas
CAS number1233082-79-5
Chemical formulaC₃₁H₂₃NO₆
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (25 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Regulatory Review
ReferencesOh, S., et al. 2010. J. Med. Chem. 53, 7405.