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504844 7-Chlorokynurenic Acid Sodium Salt - CAS 1263094-00-3 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
1263094-00-3C₁₀H₅ClNNaO₃

Products

Catalogue NumberPackaging Qty/Pack
5.04844.0001 Glass bottle 10 mg
Description
OverviewA very potent, water-soluble antagonist of the NMDA receptors complex acting at the strychnine-insensitive glycine binding site (IC50 = 0.56 µM). Also a potent inhibitor of glutamate transporter. Often used in studies of neuroprotection and schizophrenia.
Catalogue Number504844
Brand Family Calbiochem®
Synonyms7-Chloro-4-hydroxyquinoline-2-carbo-xylic acid sodium salt
References
ReferencesKemp, J., et al. 1988. Proc. Natl. Acad. Sci. U.S.A. 85, 6550.
Kretschmer, D., et al. 1995. Eur. J. Pharmacol. 280, 37.
Bartlett, D., et al. 1999. Neuropharmacol. 37, 839.
Moroni, F., et al. 1991. Eur. J. Pharmacol. 199, 32.
Stone, W., et al. 2012. FEBS J. 279, 1386.
Vécsei, L., et al. 2012. Nat. Rev. Drug Disc. 12, 64.
Product Information
CAS number1263094-00-3
FormWhite solid
Hill FormulaC₁₀H₅ClNNaO₃
Chemical formulaC₁₀H₅ClNNaO₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetNMDA receptors
Primary Target IC<sub>50</sub>0.56 →M
Purity≥99% by HPLC
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Global Trade Item Number
Catalogue Number GTIN
5.04844.0001 04055977243611