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407900 5-Iodotubercidin

5-Iodotubercidin MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-Amino-5-iodo-7-(β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine, ITU

407900
  
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Overview

Replacement Information
Description
Overview

This product has been discontinued.





A cell-permeable, potent and competitive inhibitor of the MAP kinase ERK2 (Ki = 530 nM). Also inhibits adenosine kinase (Ki = 30 nM), serine/threonine kinases such as casein kinase I and PKA, and the insulin receptor kinase fragment (IC50 = 0.4-28 µM).
Catalogue Number407900
Brand Family Calbiochem®
Synonyms4-Amino-5-iodo-7-(β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine, ITU
References
ReferencesFox, T., et al. 1998. Protein Science 7, 2249.
Parkinson, F.E., et al. 1996. J. Pharmacol. Exp. Ther. 277, 1397.
Massillon, D., et al. 1994. Biochem. J. 299, 123.
Cottam, H.B., et al. 1993. J. Med. Chem. 36, 3424.
Newby, A.C., et al. 1993. Biochem. J. 214, 317.
Product Information
CAS number24386-93-4
FormTan solid
Hill FormulaC₁₁H₁₃IN₄O₄
Chemical formulaC₁₁H₁₃IN₄O₄
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetERK2
Primary Target K<sub>i</sub>530 nM
Secondary targetadenosine kinase (IC₅₀ = 30 nM)
Purity≥90% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
407900 0

Documentation

5-Iodotubercidin Certificates of Analysis

TitleLot Number
407900

References

Reference overview
Fox, T., et al. 1998. Protein Science 7, 2249.
Parkinson, F.E., et al. 1996. J. Pharmacol. Exp. Ther. 277, 1397.
Massillon, D., et al. 1994. Biochem. J. 299, 123.
Cottam, H.B., et al. 1993. J. Med. Chem. 36, 3424.
Newby, A.C., et al. 1993. Biochem. J. 214, 317.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision04-January-2010 RFH
Synonyms4-Amino-5-iodo-7-(β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine, ITU
DescriptionA cell-permeable potent inhibitor of adenosine kinase (Ki = 30 nM) and Ser/Thr-specific kinases, such as casein kinases 1 and protein kinase A (CKI and PKA), and the insulin receptor kinase fragment (IC50 values range from 0.4-28 µM). Also shown to be a potent, and competitive inhibitor of the MAP kinase ERK2 (Ki = 530 nM).
FormTan solid
Intert gas (Yes/No) Packaged under inert gas
CAS number24386-93-4
Chemical formulaC₁₁H₁₃IN₄O₄
Structure formulaStructure formula
Purity≥90% by HPLC
SolubilityDMSO (35 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesFox, T., et al. 1998. Protein Science 7, 2249.
Parkinson, F.E., et al. 1996. J. Pharmacol. Exp. Ther. 277, 1397.
Massillon, D., et al. 1994. Biochem. J. 299, 123.
Cottam, H.B., et al. 1993. J. Med. Chem. 36, 3424.
Newby, A.C., et al. 1993. Biochem. J. 214, 317.