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538916 16,16-Dimethyl Prostaglandin E2 - CAS 39746-25-3 - Calbiochem

A cell-permeable and orally available synthetic PGE2.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 9-Oxo-11α,15R-dihydroxy-16,16-dimethyl-prosta-5Z,13E-dien-1-oic acid, dmPGE2

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Overview

Replacement Information
Description
Overview

This product has been discontinued.



A cell-permeable and orally available synthetic PGE2 (Cat. No. 538904) 16,16-dimethyl derivative that exhibits similar biological activity as PGE2 as an EP receptor agonist both in in vitro and in in vivo, while being more resistant to PGDH metabolism. Shown to amplify wnt activity through cAMP/PKA-mediated regulation of cellular β-catenin protein stability during vertebrate development and organ regeneration.
Catalogue Number538916
Brand Family Calbiochem®
Synonyms9-Oxo-11α,15R-dihydroxy-16,16-dimethyl-prosta-5Z,13E-dien-1-oic acid, dmPGE2
References
ReferencesGoessling, W., et al. 2009. Cell 136, 1136.
Fitzgerald, J., et al. 2000. Endocrinology 141, 291.
Coleman, R.A., et al. 1994. Pharmacol. Rev. 46, 205.
Product Information
CAS number39746-25-3
FormLiquid
FormulationSupplied as a solution in methylacetate (1 mg/100 µL)
Hill FormulaC₂₂H₃₆O₅
Chemical formulaC₂₂H₃₆O₅
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 11-36-66-67

Highly flammable.
Irritating to eyes.
Repeated exposure may cause skin dryness or cracking.
Vapors may cause drowsiness and dizziness.
S PhraseS: 16-2-26-29-33

Keep away from sources of ignition - No Smoking.
Keep out of the reach of children.
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Do not empty into drains.
Take precautionary measures against static discharges.
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Flammable
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage ≤ -70°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution in DMSO or EtOH store at ≤-70°C for up to 6 months; Store aqueous solutions on ice and use within 12 hrs.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
538916 0

Documentation

16,16-Dimethyl Prostaglandin E2 - CAS 39746-25-3 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

16,16-Dimethyl Prostaglandin E2 - CAS 39746-25-3 - Calbiochem Certificates of Analysis

TitleLot Number
538916

References

Reference overview
Goessling, W., et al. 2009. Cell 136, 1136.
Fitzgerald, J., et al. 2000. Endocrinology 141, 291.
Coleman, R.A., et al. 1994. Pharmacol. Rev. 46, 205.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision18-May-2010 RFH
Synonyms9-Oxo-11α,15R-dihydroxy-16,16-dimethyl-prosta-5Z,13E-dien-1-oic acid, dmPGE2
DescriptionA cell-permeable and orally available synthetic PGE2 (Cat. No. 538904) 16,16-dimethyl derivative that exhibits similar biological activity as PGE2 as an EP receptor agonist both in in vitro and in in vivo, while being more resistant to PGDH metabolism. Shown to amplify wnt activity through cAMP/PKA-mediated regulation of cellular β-catenin protein stability during vertebrate development and organ regeneration.
FormLiquid
FormulationSupplied as a solution in methylacetate (1 mg/100 µL)
Intert gas (Yes/No) Packaged under inert gas
CAS number39746-25-3
Chemical formulaC₂₂H₃₆O₅
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (100 mg/ml), EtOH (100 mg/ml), PBS, pH 7.2 (5 mg/ml). Gently blow away methylacetate under a stream of N2, and solubilize in either DMSO or EtOH purged with an inert gas.
Storage Protect from light
≤ -70°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution in DMSO or EtOH store at ≤-70°C for up to 6 months; Store aqueous solutions on ice and use within 12 hrs.
Toxicity Flammable
ReferencesGoessling, W., et al. 2009. Cell 136, 1136.
Fitzgerald, J., et al. 2000. Endocrinology 141, 291.
Coleman, R.A., et al. 1994. Pharmacol. Rev. 46, 205.