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251010 1-β-D-Arabinofuranosylcytosine - CAS 147-94-4 - Calbiochem

Anticancer, antiviral agent that is especially effective against leukemias.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Ara-C, Cytarabine, Cytosine Arabinoside

Primary Target: Anticancer, antiviral agent that is especially effective against leukemias
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251010
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
147-94-4C₉H₁₃N₃O₅

Products

Catalogue NumberPackaging Qty/Pack
251010-1GM Plastic ampoule 1 gm
Description
OverviewAnticancer, antiviral agent that is especially effective against leukemias. Induces apoptosis in human myeloid leukemia cells and in rat sympathetic neurons. Induces G1/S phase cell cycle arrest.
Catalogue Number251010
Brand Family Calbiochem®
SynonymsAra-C, Cytarabine, Cytosine Arabinoside
References
ReferencesZarilli, R., et al. 1999. Gastroenterology 116, 1358.
Dessi, F., et al. 1995. J. Neurochem. 64, 1980.
Grant, S., et al. 1994. Oncol. Res. 6, 87.
Greenberg, A.L., et al. 1994. Cancer 74, 1261.
Perrino, F.W., et al. 1997. J. Biol. Chem. 269, 16357.
Tomkins, C.E., et al. 1994. J. Cell Sci. 107, 1499.
Taddie, J.A., and Traktman, P. 1993. J. Virol. 67, 4323.
Brach, M.A., et al. 1992. Mol. Pharmacol. 41, 60.
Este, E., et al. 1992. Blood 79, 2246.
Owens, J.K., et al. 1992. Cancer Res. 52, 2389.
Product Information
CAS number147-94-4
ATP CompetitiveN
FormWhite solid
Hill FormulaC₉H₁₃N₃O₅
Chemical formulaC₉H₁₃N₃O₅
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetAnticancer, antiviral agent that is especially effective against leukemias
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSHA5425000
Safety Information
R PhraseR: 20/21/22-36/37/38-43-61

Harmful by inhalation, in contact with skin and if swallowed.
Irritating to eyes, respiratory system and skin.
May cause sensitization by skin contact.
May cause harm to the unborn child.
S PhraseS: 22-36-45

Do not breathe dust.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful & Carcinogenic / Teratogenic
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 6 months at -70°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
251010-1GM 04055977199192

Documentation

1-β-D-Arabinofuranosylcytosine - CAS 147-94-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

1-β-D-Arabinofuranosylcytosine - CAS 147-94-4 - Calbiochem Certificates of Analysis

TitleLot Number
251010

References

Reference overview
Zarilli, R., et al. 1999. Gastroenterology 116, 1358.
Dessi, F., et al. 1995. J. Neurochem. 64, 1980.
Grant, S., et al. 1994. Oncol. Res. 6, 87.
Greenberg, A.L., et al. 1994. Cancer 74, 1261.
Perrino, F.W., et al. 1997. J. Biol. Chem. 269, 16357.
Tomkins, C.E., et al. 1994. J. Cell Sci. 107, 1499.
Taddie, J.A., and Traktman, P. 1993. J. Virol. 67, 4323.
Brach, M.A., et al. 1992. Mol. Pharmacol. 41, 60.
Este, E., et al. 1992. Blood 79, 2246.
Owens, J.K., et al. 1992. Cancer Res. 52, 2389.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-April-2019 JSW
SynonymsAra-C, Cytarabine, Cytosine Arabinoside
DescriptionCytosine analog that acts as a potent inhibitor of eukaryotic cellular and viral replicative DNA synthesis. AraCTP, formed by intracellular phosphorylation of AraC, is utilized as a substrate by DNA polymerases, which incorporate AraCMP residues into DNA. Incorporated 3'-terminal AraCMP residues inhibit further DNA synthesis by impeding chain elongation by DNA polymerase. AraC is used clinically in the treatment of various cancers, particularly leukemias and lymphomas. Also used to inhibit proliferation of cultured cells and replication of eukaryotic viruses (e.g. vaccinia virus, herpes simplex virus). Also shown to induce apoptosis in human myeloid leukemia cells and in post-mitotic rat sympathetic neurons.
FormWhite solid
CAS number147-94-4
RTECSHA5425000
Chemical formulaC₉H₁₃N₃O₅
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityH₂O (1 mM)
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 6 months at -70°C.
Toxicity Harmful & Carcinogenic / Teratogenic
Merck USA index14, 2784
ReferencesZarilli, R., et al. 1999. Gastroenterology 116, 1358.
Dessi, F., et al. 1995. J. Neurochem. 64, 1980.
Grant, S., et al. 1994. Oncol. Res. 6, 87.
Greenberg, A.L., et al. 1994. Cancer 74, 1261.
Perrino, F.W., et al. 1997. J. Biol. Chem. 269, 16357.
Tomkins, C.E., et al. 1994. J. Cell Sci. 107, 1499.
Taddie, J.A., and Traktman, P. 1993. J. Virol. 67, 4323.
Brach, M.A., et al. 1992. Mol. Pharmacol. 41, 60.
Este, E., et al. 1992. Blood 79, 2246.
Owens, J.K., et al. 1992. Cancer Res. 52, 2389.