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343781 ω-Conotoxin GVIA, Conus geographus - CAS 106375-28-4 - Calbiochem

A neurotoxin that acts as an antagonist of voltage-activated N-type Ca2+ channels and of neurotransmitter release at neuronal synapses.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: ω-CgTx GVIA

Primary Target: Voltage-activated N-type Ca2+ channels
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
106375-28-4C₁₂₀H₁₈₂N₃₈O₄₃S₆

Products

Catalogue NumberPackaging Qty/Pack
343781-100UG Alu drum 100 μg
Description
OverviewA neurotoxin that acts as an antagonist of voltage-activated N-type Ca2+ channels and of neurotransmitter release at neuronal synapses. Its antagonistic activity is attributed to a tyrosine residue at position 13. Does not bind to dihydropyridine- or verapamil-binding sites. Also reported to inhibit ATP-induced inward currents mediated by P2X2/X3 receptors (IC50 = 21.2 nM for P2X3 and 3.84 µM for P2X2/X3 heterooligomeric receptors).
Catalogue Number343781
Brand Family Calbiochem®
Synonymsω-CgTx GVIA
References
ReferencesLalo, U.V., et al. 2001. Brain Res. Bull. 54, 507.
Kim, J.I., et al. 1995. Biochem. Biophys. Res. Commun. 206, 449.
Abbott, J.R., and Litzinger, M.J. 1994. Int. J. Dev. Neurosci. 12, 43.
Olivera, B.M., et al. 1991. J. Biol. Chem. 266, 22067.
Protti, D.A., et al. 1991. Brain Res. 557, 336.
Werth, J.L., et al. 1991. Mol. Pharmacol. 40, 742.
Koyano, K., et al. 1987. Eur. J. Pharmacol. 135, 337.
Abe, T., et al. 1986. Neurosci. Lett. 71, 203.
Product Information
CAS number106375-28-4
ATP CompetitiveN
DeclarationNot available for sale outside of the United States.
FormLyophilized
Hill FormulaC₁₂₀H₁₈₂N₃₈O₄₃S₆
Chemical formulaC₁₂₀H₁₈₂N₃₈O₄₃S₆
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetVoltage-activated N-type Ca2+ channels
Primary Target IC<sub>50</sub>21.2 nM for P2X3 and 3.84 µM for P2X2/X3 heterooligomeric receptors
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Peptide SequenceH-Cys¹-Lys-Ser-Hyp-Gly-Ser-Ser-Cys⁸-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys¹⁵-Cys¹⁶-Arg-Ser-Cys¹⁹-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys²⁶-Tyr-NH₂ (disulfide bonds: 1 → 16; 8 → 19; 15 → 26)
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 26/27/28

Very toxic by inhalation, in contact with skin and if swallowed.
S PhraseS: 45-36/37/39

In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Wear suitable protective clothing, gloves and eye/face protection.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Highly Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
End use certificateY
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
343781-100UG 04055977195125

Documentation

ω-Conotoxin GVIA, Conus geographus - CAS 106375-28-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

ω-Conotoxin GVIA, Conus geographus - CAS 106375-28-4 - Calbiochem Certificates of Analysis

TitleLot Number
343781

References

Reference overview
Lalo, U.V., et al. 2001. Brain Res. Bull. 54, 507.
Kim, J.I., et al. 1995. Biochem. Biophys. Res. Commun. 206, 449.
Abbott, J.R., and Litzinger, M.J. 1994. Int. J. Dev. Neurosci. 12, 43.
Olivera, B.M., et al. 1991. J. Biol. Chem. 266, 22067.
Protti, D.A., et al. 1991. Brain Res. 557, 336.
Werth, J.L., et al. 1991. Mol. Pharmacol. 40, 742.
Koyano, K., et al. 1987. Eur. J. Pharmacol. 135, 337.
Abe, T., et al. 1986. Neurosci. Lett. 71, 203.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision24-June-2008 RFH
Synonymsω-CgTx GVIA
DescriptionA neurotoxin that acts as an antagonist of voltage-activated N-type Ca2+ channels and of neurotransmitter release at neuronal synapses. Its antagonistic activity is attributed to a tyrosine residue at position 13. Does not bind to dihydropyridine- or verapamil-binding sites. Also reported to inhibit ATP-induced inward currents mediated by P2X2/X3 receptors (IC50 = 21.2 nM for P2X3 and 3.84 µM for P2X2/X3 heterooligomeric receptors).
FormLyophilized
CAS number106375-28-4
Chemical formulaC₁₂₀H₁₈₂N₃₈O₄₃S₆
Peptide SequenceH-Cys¹-Lys-Ser-Hyp-Gly-Ser-Ser-Cys⁸-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys¹⁵-Cys¹⁶-Arg-Ser-Cys¹⁹-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys²⁶-Tyr-NH₂ (disulfide bonds: 1 → 16; 8 → 19; 15 → 26)
Purity≥98% by HPLC
SolubilityH₂O (250 µg/ml) or aqueous buffers
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Highly Toxic
ReferencesLalo, U.V., et al. 2001. Brain Res. Bull. 54, 507.
Kim, J.I., et al. 1995. Biochem. Biophys. Res. Commun. 206, 449.
Abbott, J.R., and Litzinger, M.J. 1994. Int. J. Dev. Neurosci. 12, 43.
Olivera, B.M., et al. 1991. J. Biol. Chem. 266, 22067.
Protti, D.A., et al. 1991. Brain Res. 557, 336.
Werth, J.L., et al. 1991. Mol. Pharmacol. 40, 742.
Koyano, K., et al. 1987. Eur. J. Pharmacol. 135, 337.
Abe, T., et al. 1986. Neurosci. Lett. 71, 203.