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122302 ω-Agatoxin TK, Agelenopsis aperta

Specific P-type calcium channel blocker with no apparent effect on L-type, N-type, and T-type channels.

ω-Agatoxin TK, Agelenopsis aperta MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: ω-Aga-TK

Primary Target: Specific P-type calcium channel blocker
122302
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
145017-83-0C₂₁₅H₃₃₇N₆₅O₇₀S₁₀
Description
Overview

This product has been discontinued.





Specific P-type calcium channel blocker with no apparent effect on L-type, N-type, and T-type channels. Useful tool for investigating the role of P-type calcium channels in the peripheral and central nervous systems. Also inhibits the release of amino acid transmitters and monoamines.
Catalogue Number122302
Brand Family Calbiochem®
Synonymsω-Aga-TK
References
ReferencesKimura, M., et al. 1995. Neuroscience 66, 609.
Teramoto, T., et al. 1995. NeuroReport 6, 1684.
Teramoto, T., et al. 1993. Biochem. Biophys. Res. Commun. 196, 134.
Product Information
CAS number145017-83-0
ATP CompetitiveN
FormLyophilized
Hill FormulaC₂₁₅H₃₃₇N₆₅O₇₀S₁₀
Chemical formulaC₂₁₅H₃₃₇N₆₅O₇₀S₁₀
ReversibleN
Applications
Biological Information
Biological activityShown to inhibit K+-induced ³H-GABA release from primary rat hippocampal neurons
Primary TargetSpecific P-type calcium channel blocker
Purity≥99% by HPLC
Physicochemical Information
Cell permeableN
Peptide SequenceH-Glu-Asp-Asn-Cys⁴-Ile-Ala-Glu-Asp-Tyr-Gly-Lys-Cys¹²-Thr-Trp-Gly-Gly-Thr-Lys-Cys¹⁹-Cys²⁰-Arg-Gly-Arg-Pro-Cys²⁵-Arg-Cys²⁷-Ser-Met-Ile-Gly-Thr-Asn-Cys³⁴-Glu-Cys³⁶-Thr-Pro-Arg-Leu-Ile-Met-Glu-Gly-Leu-Ser-Phe-Ala-OH (disulfide bonds: 4 → 20; 12 → 25; 19 → 36; 27 → 34)
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 20/21/22

Harmful by inhalation, in contact with skin and if swallowed.
S PhraseS: 36

Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. This product is stable for up to 1 week at 4°C or for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
122302 0

Documentation

ω-Agatoxin TK, Agelenopsis aperta Certificates of Analysis

TitleLot Number
122302

References

Reference overview
Kimura, M., et al. 1995. Neuroscience 66, 609.
Teramoto, T., et al. 1995. NeuroReport 6, 1684.
Teramoto, T., et al. 1993. Biochem. Biophys. Res. Commun. 196, 134.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision08-April-2008 RFH
Synonymsω-Aga-TK
DescriptionSpecific P-type calcium channel blocker with no apparent effect on L-type, N-type, and T-type channels. Useful tool for investigating the role of P-type calcium channels in the peripheral and central nervous systems. Also inhibits the release of amino acid transmitters and monoamines.
FormLyophilized
CAS number145017-83-0
Chemical formulaC₂₁₅H₃₃₇N₆₅O₇₀S₁₀
Peptide SequenceH-Glu-Asp-Asn-Cys⁴-Ile-Ala-Glu-Asp-Tyr-Gly-Lys-Cys¹²-Thr-Trp-Gly-Gly-Thr-Lys-Cys¹⁹-Cys²⁰-Arg-Gly-Arg-Pro-Cys²⁵-Arg-Cys²⁷-Ser-Met-Ile-Gly-Thr-Asn-Cys³⁴-Glu-Cys³⁶-Thr-Pro-Arg-Leu-Ile-Met-Glu-Gly-Leu-Ser-Phe-Ala-OH (disulfide bonds: 4 → 20; 12 → 25; 19 → 36; 27 → 34)
Purity≥99% by HPLC
Biological activityShown to inhibit K+-induced ³H-GABA release from primary rat hippocampal neurons
SolubilityH₂O (1 mg/ml) or 0.9% NaCl (1 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. This product is stable for up to 1 week at 4°C or for up to 3 months at -20°C.
Toxicity Harmful
ReferencesKimura, M., et al. 1995. Neuroscience 66, 609.
Teramoto, T., et al. 1995. NeuroReport 6, 1684.
Teramoto, T., et al. 1993. Biochem. Biophys. Res. Commun. 196, 134.