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Genomic instability | Life Science Research | Merck
Learn about the environmental factors that can hinder DNA repair. There are many evidence linking genomic and epigenomic changes to disorders involving accelerated aging. Evidence points to general physiological stress and disrupted circadian. It is also possible that decreased DNA repair is also a symptom, not a cause, of aging. To investigate this possibility, researchers will need to examine changes in transcriptional regulators of repair genes, such as ncRNAs, hormones, and other chromatin modulators.
DNA Damage & TUNEL Assays | Life Science Research | Merck
DNA damage and TUNEL assays are used to examine DNA fragmentation in apoptosis to get some data about DNA damage as it is related to the apoptotic process.
Nuclear Function | Life Science Research | Merck
A Nuclear function is to be home of an entire genome that can physically fit inside the nucleus and to allow the cell to differentiate, divide, and endure environmental stresses while protecting its valuable genetic information.