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682160 Xestospongin C, Xestospongia sp. - Calbiochem

Xestospongin C, Xestospongia sp. CAS 88903-69-9, is a highly potent, reversible, and membrane-permeable blocker of IP3-mediated Ca2+ release (IC50 = 358 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: XeC

Primary Target: IP3-mediated Ca2+ release
682160
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₈H₅₀N₂O₂

Products

Catalogue NumberPackaging Qty/Pack
682160-10UG Plastic ampoule 10 μg
Description
OverviewAn oxaquinolizidine alkaloid isolated from a marine sponge. A very potent, reversible, and membrane-permeable blocker of IP3-mediated Ca2+ release (IC50 = 358 nM) that does not interact with the IP3-binding site. Displays high selectivity over the skeletal isoform of the ryanodine receptor type 1 (RyR-1). Also blocks bradykinin- and carbamylcholine-induced Ca2+ efflux from the endoplasmic reticulum stores in a reversible manner.
Catalogue Number682160
Brand Family Calbiochem®
SynonymsXeC
References
ReferencesOka, T., et al. 2002. Br. J. Pharmacol. 135, 1959.
Gafni, J., et al. 1997. Neuron 19, 723.
Tinker, A., and Williams, A.J. 1995. Biophys. J. 68, 111.
Callaway, C., et al. 1994. J. Biol. Chem. 269, 15876.
Quirion, J.C., et al. 1992. J. Nat. Prod. 55, 1505.
Nakagawa, M., et al. 1984. Tetrahedron Lett. 25, 3227.
Product Information
ATP CompetitiveN
FormWhite to off-white film
Hill FormulaC₂₈H₅₀N₂O₂
Chemical formulaC₂₈H₅₀N₂O₂
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationXestospongin C, Xestospongia sp. CAS 88903-69-9, is a highly potent, reversible, and membrane-permeable blocker of IP3-mediated Ca2+ release (IC50 = 358 nM).
Biological Information
Primary TargetIP3-mediated Ca2+ release
Primary Target IC<sub>50</sub>358 nM in blocking IP3-mediated Ca2+ release
Purity≥98% by TLC or HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 20/21/22

Harmful by inhalation, in contact with skin and if swallowed.
S PhraseS: 22-24/25-36/37/39-45

Do not breathe dust.
Avoid contact with skin and eyes.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
682160-10UG 07790788052355

Documentation

Xestospongin C, Xestospongia sp. - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Xestospongin C, Xestospongia sp. - Calbiochem Certificates of Analysis

TitleLot Number
682160

References

Reference overview
Oka, T., et al. 2002. Br. J. Pharmacol. 135, 1959.
Gafni, J., et al. 1997. Neuron 19, 723.
Tinker, A., and Williams, A.J. 1995. Biophys. J. 68, 111.
Callaway, C., et al. 1994. J. Biol. Chem. 269, 15876.
Quirion, J.C., et al. 1992. J. Nat. Prod. 55, 1505.
Nakagawa, M., et al. 1984. Tetrahedron Lett. 25, 3227.

Citations

Title
  • M. Keith Wilkerson, et al. (2006) Inositol triphosphate receptor calcium release is required for cerebral artery smooth muscle cell proliferation. American Journal of Physiology Heart and Circulatory Physiology 290, H240-H247.
  • Tobi L. Limke, Jeremy J. Bearss and William D. Atchison. (2004) Acute Exposure to Methylmercury Causes Ca2+ Dysregulation and Neuronal Death in Rat Cerebellar Granule Cells through an M3 Muscarinic Receptor-Linked Pathway. Toxicological Sciences 80, 60-68.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision13-October-2020 JSW
    SynonymsXeC
    DescriptionA macrocyclic bis-1-oxaquinolizidine natural product isolated from a marine sponge. A very potent, reversible and membrane-permeable blocker of IP3-mediated Ca2+ release (IC50 = 358 nM) that does not interact with the IP3-binding site. Displays high selectivity over the skeletal isoform of the ryanodine receptor type 1 (Ry1R). Also blocks bradykinin- and carbamylcholine-induced Ca2+ efflux from the ER stores in a reversible manner.
    FormWhite to off-white film
    Intert gas (Yes/No) Packaged under inert gas
    Chemical formulaC₂₈H₅₀N₂O₂
    Structure formulaStructure formula
    Purity≥98% by TLC or HPLC
    SolubilityDMSO (1 mg/ml), Ethanol (1 mg/ml), or Methanol (1 mg/ml). Sonication may be required to achieve complete solubilization.
    Storage Protect from light
    -20°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    Toxicity Harmful
    ReferencesOka, T., et al. 2002. Br. J. Pharmacol. 135, 1959.
    Gafni, J., et al. 1997. Neuron 19, 723.
    Tinker, A., and Williams, A.J. 1995. Biophys. J. 68, 111.
    Callaway, C., et al. 1994. J. Biol. Chem. 269, 15876.
    Quirion, J.C., et al. 1992. J. Nat. Prod. 55, 1505.
    Nakagawa, M., et al. 1984. Tetrahedron Lett. 25, 3227.
    Citation
  • M. Keith Wilkerson, et al. (2006) Inositol triphosphate receptor calcium release is required for cerebral artery smooth muscle cell proliferation. American Journal of Physiology Heart and Circulatory Physiology 290, H240-H247.
  • Tobi L. Limke, Jeremy J. Bearss and William D. Atchison. (2004) Acute Exposure to Methylmercury Causes Ca2+ Dysregulation and Neuronal Death in Rat Cerebellar Granule Cells through an M3 Muscarinic Receptor-Linked Pathway. Toxicological Sciences 80, 60-68.
    		•